| Title |
Alternative splicing in the dyslexia-associated gene KIAA0319
|
|---|---|
| Published in |
Mammalian Genome, September 2007
|
| DOI | 10.1007/s00335-007-9051-3 |
| Pubmed ID | |
| Authors |
Antonio Velayos-Baeza, Claudio Toma, Stephanie da Roza, Silvia Paracchini, Anthony P. Monaco |
| Abstract |
The KIAA0319 gene in chromosome 6p22 has been strongly associated with developmental dyslexia. In this article we show a wide expression pattern of this gene in human adult brain by Northern blot analysis. We also performed RT-PCR analysis to detect alternative splicing variants in human brain. Most of the detected variants involve alternative splicing of the exons at the 5' and the 3' ends. Two main forms differing in the length of the 5' UTR are detected at approximately the same rate. Two variants (B and C) lacking exon 19, which encodes the transmembrane domain, are the main alternative forms detected among those predicted to encode protein. These two variants could be secreted and might be involved in signaling functions. A similar RT-PCR analysis performed in mouse and rat adult brains showed that only some of the alternative splicing variants are equivalent to those found in the human gene. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Netherlands | 1 | 3% |
| Unknown | 35 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 16% |
| Professor | 6 | 16% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Master | 5 | 14% |
| Researcher | 4 | 11% |
| Other | 7 | 19% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 43% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Medicine and Dentistry | 3 | 8% |
| Psychology | 2 | 5% |
| Nursing and Health Professions | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 6 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,759,452
of 25,837,817 outputs
Outputs from Mammalian Genome
#352
of 1,118 outputs
Outputs of similar age
#30,076
of 84,316 outputs
Outputs of similar age from Mammalian Genome
#4
of 5 outputs
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