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Mendeley readers
Attention Score in Context
| Title |
A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, March 1997
|
| DOI | 10.1073/pnas.94.5.1914 |
| Pubmed ID | |
| Authors |
Yao-Tseng Chen, Matthew J. Scanlan, Ugur Sahin, Özlem Türeci, Ali O. Gure, Solam Tsang, Barbara Williamson, Elisabeth Stockert, Michael Pfreundschuh, Lloyd J. Old |
| Abstract |
Serological analysis of recombinant cDNA expression libraries (SEREX) using tumor mRNA and autologous patient serum provides a powerful approach to identify immunogenic tumor antigens. We have applied this methodology to a case of esophageal squamous cell carcinoma and identified several candidate tumor targets. One of these, NY-ESO-1, showed restricted mRNA expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma. NY-ESO-1 encodes a putative protein of Mr 17,995 having no homology with any known protein. The pattern of NY-ESO-1 expression indicates that it belongs to an expanding family of immunogenic testicular antigens that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. These antigens, initially detected by either cytotoxic T cells (MAGE, BAGE, GAGE-1) or antibodies [HOM-MEL-40(SSX2), NY-ESO-1], represent a pool of antigenic targets for cancer vaccination. |
Mendeley readers
The data shown below were compiled from readership statistics for 339 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Israel | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 330 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 90 | 27% |
| Researcher | 55 | 16% |
| Student > Master | 40 | 12% |
| Student > Bachelor | 22 | 6% |
| Student > Doctoral Student | 18 | 5% |
| Other | 40 | 12% |
| Unknown | 74 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 24% |
| Biochemistry, Genetics and Molecular Biology | 57 | 17% |
| Medicine and Dentistry | 50 | 15% |
| Immunology and Microbiology | 46 | 14% |
| Chemistry | 5 | 1% |
| Other | 20 | 6% |
| Unknown | 79 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#2,393,489
of 26,017,215 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#27,842
of 104,451 outputs
Outputs of similar age
#1,026
of 29,721 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#29
of 458 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 104,451 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 29,721 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 458 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.