Title |
Cell cycle regulation by the ubiquitin pathway
|
---|---|
Published in |
FASEB Journal, November 1997
|
DOI | 10.1096/fasebj.11.13.9367342 |
Pubmed ID | |
Authors |
Michele Pagano |
Abstract |
In the past 2 years, two ubiquitin-dependent proteolytic pathways have been established as important players in the regulation of the cell division cycle. In S. cerevisiae, the entry into S phase requires ubiquitin-mediated degradation of a cdk inhibitor, p40Sic1, in a pathway that involves the E2 enzyme Cdc34. Recent studies reviewed herein show that the Cdc34 pathway targets phosphorylated substrates. A second pathway that regulates chromosome segregation and mitotic exit by degrading anaphase inhibitors and mitotic cyclins involves a different E2 and a large molecular weight E3 complex, called the anaphase-promoting complex or cyclosome. This pathway targets substrates containing one or more destruction box motif. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
United Kingdom | 1 | 1% |
Germany | 1 | 1% |
Unknown | 64 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 29% |
Student > Bachelor | 9 | 13% |
Professor | 7 | 10% |
Researcher | 7 | 10% |
Student > Master | 7 | 10% |
Other | 11 | 16% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 40% |
Biochemistry, Genetics and Molecular Biology | 21 | 31% |
Immunology and Microbiology | 4 | 6% |
Physics and Astronomy | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 5 | 7% |
Unknown | 8 | 12% |