Title |
MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma
|
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Published in |
Microchimica Acta, April 2018
|
DOI | 10.1007/s00604-018-2779-5 |
Pubmed ID | |
Authors |
Junxin Lai, Tingjian Wang, Hao Wang, Fengqiang Shi, Wei Gu, Ling Ye |
Abstract |
The authors describe MnO nanoparticles (NPs) with unique excitation-dependent fluorescence across the entire visible spectrum. These NPs are shown to be efficient optical nanoprobe for multicolor cellular imaging. Synthesis of the NPs is accomplished by a thermal decomposition method. The MnO NPs exhibit a high r1relaxivity of 4.68 mM-1 s-1and therefore give an enhanced contrast effect in magnetic resonance (MR) studies of brain glioma. The cytotoxicity assay, hemolysis analysis, and hematoxylin and eosin (H&E) staining tests verify that the MnO NPs are biocompatible. In the authors' perception, the simultaneous attributes of multicolor fluorescence and excellent MR functionality make this material a promising dual-modal nanoprobe for use in bio-imaging. Graphical abstract A direct method to synthesize fluorescent MnO NPs is reported. The NPs are biocompatible and have been successfully applied for multicolor cellular imaging and MR detection of brain glioma. |
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Portugal | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 20% |
Student > Master | 3 | 20% |
Professor | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Researcher | 1 | 7% |
Other | 0 | 0% |
Unknown | 6 | 40% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Medicine and Dentistry | 2 | 13% |
Physics and Astronomy | 1 | 7% |
Neuroscience | 1 | 7% |
Chemistry | 1 | 7% |
Other | 2 | 13% |
Unknown | 6 | 40% |