| Title |
B cell-restricted human mb-1 gene
|
|---|---|
| Published in |
Immunologic Research, January 2002
|
| DOI | 10.1385/ir:26:1-3:035 |
| Pubmed ID | |
| Authors |
Bettie Herren, Peter D. Burrows |
| Abstract |
The antigen receptor on B cells (B cell receptor [BCR]) consists of two noncovalently associated modules. Immunoglobulin genes created somatically during B cell development encode the antigen-specific component of the receptor. The Igalpha/beta heterodimer, encoded by the mb-1 and B29 genes, is necessary to escort the receptor complex to the plasma membrane. Following antigen engagement of the BCR, Igalpha/beta nucleates signal transduction and promotes endocytosis of bound antigen for intracellular degradation and presentation to helper T-cells. In this review, we outline the discovery of the mb-1 gene; summarize results from other laboratories on the function of Igalpha/beta in B cells; and conclude with our recent studies, which indicate that mb-1 is not a B-lineage-restricted gene as originally proposed. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 33% |
| Student > Ph. D. Student | 2 | 22% |
| Professor | 1 | 11% |
| Student > Master | 1 | 11% |
| Student > Postgraduate | 1 | 11% |
| Other | 0 | 0% |
| Unknown | 1 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 33% |
| Immunology and Microbiology | 3 | 33% |
| Medicine and Dentistry | 2 | 22% |
| Agricultural and Biological Sciences | 1 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2021.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Immunologic Research
#315
of 948 outputs
Outputs of similar age
#32,445
of 130,773 outputs
Outputs of similar age from Immunologic Research
#6
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
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