| Title |
Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype
|
|---|---|
| Published in |
Journal of Neural Transmission, January 2007
|
| DOI | 10.1007/s00702-006-0609-0 |
| Pubmed ID | |
| Authors |
M. Reimold, M. N. Smolka, G. Schumann, A. Zimmer, J. Wrase, K. Mann, X.-Z. Hu, D. Goldman, G. Reischl, C. Solbach, H.-J. Machulla, R. Bares, A. Heinz |
| Abstract |
Homozygote carriers of two long (L) alleles of the serotonin transporter (5-HTT) regulatory region displayed in vitro a twofold increase in 5-HTT expression compared with carriers of one or two short (S) alleles. However, in vivo imaging studies yielded contradictory results. Recently, an A > G exchange leading to differential transcriptional activation of 5-HTT mRNA in lymphobalstoid cell lines was discovered in the 5-HTT regulatory region. In vitro and in vivo evidence suggests that [(11)C]DASB, a new 5-HTT ligand offers some advantages over the ligands used in previous studies in measuring 5-HTT density independent of synaptic levels of serotonin. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 2% |
| Sweden | 1 | 2% |
| Costa Rica | 1 | 2% |
| Canada | 1 | 2% |
| Singapore | 1 | 2% |
| Denmark | 1 | 2% |
| Unknown | 58 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 20% |
| Researcher | 11 | 17% |
| Student > Master | 10 | 16% |
| Professor > Associate Professor | 8 | 13% |
| Student > Bachelor | 5 | 8% |
| Other | 10 | 16% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 14 | 22% |
| Agricultural and Biological Sciences | 13 | 20% |
| Medicine and Dentistry | 10 | 16% |
| Neuroscience | 10 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Other | 3 | 5% |
| Unknown | 11 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2008.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Journal of Neural Transmission
#631
of 1,764 outputs
Outputs of similar age
#43,193
of 159,868 outputs
Outputs of similar age from Journal of Neural Transmission
#3
of 8 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,764 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,868 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.