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Mendeley readers
Attention Score in Context
| Title |
Adhesion of human T cells to antigen-presenting cells through SIRPβ2-CD47 interaction costimulates T-cell proliferation
|
|---|---|
| Published in |
Blood, September 2004
|
| DOI | 10.1182/blood-2004-07-2823 |
| Pubmed ID | |
| Authors |
Laura Piccio, William Vermi, Kent S. Boles, Anja Fuchs, Carey A. Strader, Fabio Facchetti, Marina Cella, Marco Colonna |
| Abstract |
Signal-regulatory proteins (SIRPs) are transmembrane glycoproteins belonging to the immunoglobulin (Ig) superfamily that are expressed in the immune and central nervous systems. SIRPalpha binds CD47 and inhibits the function of macrophages, dendritic cells, and granulocytes, whereas SIRPbeta1 is an orphan receptor that activates the same cell types. A recently identified third member of the SIRP family, SIRPbeta2, is as yet uncharacterized in terms of expression, specificity, and function. Here, we show that SIRPbeta2 is expressed on T cells and activated natural killer (NK) cells and, like SIRPalpha, binds CD47, mediating cell-cell adhesion. Consequently, engagement of SIRPbeta2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation. |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Germany | 1 | 1% |
| Unknown | 84 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 28% |
| Researcher | 20 | 23% |
| Student > Master | 8 | 9% |
| Other | 6 | 7% |
| Professor > Associate Professor | 6 | 7% |
| Other | 13 | 15% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 40% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Medicine and Dentistry | 11 | 13% |
| Immunology and Microbiology | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 2 | 2% |
| Unknown | 15 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2024.
All research outputs
#3,798,945
of 25,374,917 outputs
Outputs from Blood
#4,890
of 33,238 outputs
Outputs of similar age
#6,830
of 73,436 outputs
Outputs of similar age from Blood
#25
of 210 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,238 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 73,436 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.