| Title |
Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues
|
|---|---|
| Published in |
Histochemistry and Cell Biology, November 2003
|
| DOI | 10.1007/s00418-003-0596-2 |
| Pubmed ID | |
| Authors |
Kwong-Tai Cheng, Franky Leung Chan, Yu Huang, Wing-Yee Chan, Xiaoqiang Yao |
| Abstract |
Cyclic nucleotide-gated (CNG) ion channels are Ca2+-permeable nonselective cation channels that are directly gated by the binding of cAMP or cGMP. Previous studies have identified the expression of CNGA1 channels in vascular endothelial cells. The opening of CNG channels is expected to result in a rise in endothelial cytosolic Ca2+, which may trigger multiple physiological changes. In the present study, we extensively studied the expression pattern of the functional subunit of olfactory-type CNG channels (CNGA2) in vascular tissues. Northern blot analysis detected a transcript of approximately 2.6 kb in mRNA isolated from rat aorta. RT-PCR amplified a 582-bp CNGA2 fragment from RNA samples isolated from rat aorta, bovine endothelia cell CCL-209, and rat smooth muscle cell A7r5. Furthermore, in situ hybridization and immunohistochemistry revealed that CNGA2 mRNA and proteins were expressed in the endothelium and smooth muscle layers of human coronary and cerebral arteries. In conclusion, our study indicates that CNGA2 channels are widely expressed in vascular tissues across different species. These results suggest a potential ubiquitous role of CNGA2 channels in mediating Ca2+ influx in vascular cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 21% |
| Student > Bachelor | 3 | 16% |
| Professor | 3 | 16% |
| Student > Ph. D. Student | 3 | 16% |
| Professor > Associate Professor | 3 | 16% |
| Other | 2 | 11% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 47% |
| Medicine and Dentistry | 4 | 21% |
| Computer Science | 1 | 5% |
| Neuroscience | 1 | 5% |
| Chemistry | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 3 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2008.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Histochemistry and Cell Biology
#306
of 1,236 outputs
Outputs of similar age
#21,413
of 61,052 outputs
Outputs of similar age from Histochemistry and Cell Biology
#2
of 5 outputs
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