| Title |
IL-33 attenuates mortality by promoting IFN-γ production in sepsis
|
|---|---|
| Published in |
Inflammation Research, April 2018
|
| DOI | 10.1007/s00011-018-1144-9 |
| Pubmed ID | |
| Authors |
Qi Bao, Ran Lv, Min Lei |
| Abstract |
Sepsis remains a major clinical problem with high morbidity and mortality. Interleukin (IL)-33 is a recently described member of the IL-1 family that is widely expressed and functions as a new inflammatory mediator. IL-33 has been reported to protect sepsis, but the underlying mechanisms are not well-elucidated. We measured the interferon gamma (IFN-γ) production in septic mice after IL-33 treatment. IL-33 treatment enhanced the IFN-γ level in blood and promoted mice's survival, so the protective effects of IL-33 depend on IFN-γ. The IL-33 treatment also promoted both γδ T cells and NK cells in septic mice. Our data showed that IL-33 attenuates mortality by promoting IFN-γ production in sepsis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 33% |
| Student > Ph. D. Student | 3 | 20% |
| Student > Doctoral Student | 1 | 7% |
| Student > Master | 1 | 7% |
| Researcher | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 3 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 27% |
| Medicine and Dentistry | 4 | 27% |
| Immunology and Microbiology | 4 | 27% |
| Agricultural and Biological Sciences | 1 | 7% |
| Unknown | 2 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2018.
All research outputs
#20,476,619
of 23,036,991 outputs
Outputs from Inflammation Research
#790
of 960 outputs
Outputs of similar age
#290,429
of 328,968 outputs
Outputs of similar age from Inflammation Research
#9
of 11 outputs
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