| Title |
Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia
|
|---|---|
| Published in |
Brain Structure and Function, September 2005
|
| DOI | 10.1007/s00429-005-0036-2 |
| Pubmed ID | |
| Authors |
René Hurlemann, Christian Boy, Philipp T. Meyer, Harald Scherk, Michael Wagner, Hans Herzog, Heinz H. Coenen, Kai Vogeley, Peter Falkai, Karl Zilles, Wolfgang Maier, Andreas Bauer |
| Abstract |
The brain serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathology of schizophrenia and the therapeutic action of atypical antipsychotics. However, little is known about the 5-HT(2A)R status before the onset of schizophrenia and before the exposure to antipsychotics. We used [18F] altanserin and positron emission tomography (PET) in a pilot study of 6 individuals suspected to be at elevated risk for schizophrenia and seven age-matched controls to test the hypothesis that regional 5-HT(2A)R binding is altered in the prodromal stages of schizophrenia. Distribution volume ratios (DVRs) as a proxy for 5-HT(2A)R availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities of serotonergic neurotransmission that antecede the onset of schizophrenia. |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 51 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Researcher | 9 | 17% |
| Professor | 8 | 15% |
| Student > Bachelor | 5 | 9% |
| Student > Postgraduate | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 11 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 21% |
| Medicine and Dentistry | 9 | 17% |
| Neuroscience | 8 | 15% |
| Agricultural and Biological Sciences | 4 | 8% |
| Immunology and Microbiology | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 16 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2008.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Brain Structure and Function
#675
of 2,021 outputs
Outputs of similar age
#25,083
of 70,163 outputs
Outputs of similar age from Brain Structure and Function
#5
of 8 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,021 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,163 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.