Title |
A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40
|
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Published in |
European Biophysics Journal, June 2007
|
DOI | 10.1007/s00249-007-0187-6 |
Pubmed ID | |
Authors |
Mouna Marrakchi, Jasmina Vidic, Nicole Jaffrezic-Renault, Claude Martelet, Edith Pajot-Augy |
Abstract |
This work shows the feasibility of an olfactory biosensor based on the immobilization of Saccharomyces cerevisiae yeast cells genetically modified to express the human olfactory receptor OR17-40 onto interdigitated microconductometric electrodes. This olfactory biosensor has been applied to the detection of its specific odorant (helional) with a high sensitivity (threshold 10(-14) M). In contrast, no significant response was observed using a non-specific odorant (heptanal), which suggests a good selectivity. Thus, this work may represent a first step towards a new kind of bioelectronic noses based on whole yeast cells and allowing a real time monitoring of olfactory receptor activation. |
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