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On the applicability of high frequency acoustic shear mode biosensing in view of thickness limitations set by the film resonance

Overview of attention for article published in Biosensors & Bioelectronics, April 2009
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1 patent

Citations

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28 Mendeley
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Title
On the applicability of high frequency acoustic shear mode biosensing in view of thickness limitations set by the film resonance
Published in
Biosensors & Bioelectronics, April 2009
DOI 10.1016/j.bios.2009.04.021
Pubmed ID
Authors

G. Wingqvist, H. Anderson, C. Lennartsson, T. Weissbach, V. Yantchev, A. Lloyd Spetz

Abstract

The IC-compatible thin film bulk acoustic resonator (FBAR) technology has made it possible to move the thickness excited shear mode sensing of biological layers into a new sensing regime using substantially higher operation frequencies than the conventionally used quartz crystal microbalance (QCM). The limitations of the linear range set by the film resonance using viscoelastic protein films are here for the first time addressed specifically for FBARs operating at 700 MHz up to 1.5 GHz. Two types of protein multilayer sensing were employed; one utilizing alternating layers of streptavidin and biotinated BSA and the other using stepwise cross-linking of fibrinogen with EDC/NHS activation of its carboxyl groups. In both cases the number of protein layers within the linear regime is well above the number of protein layers usually used in biosensor applications, further verifying the applicability of the FBAR as a biosensor. Theoretical calculations are also presented using well established physical models to illustrate the expected behavior of the FBAR sensor, in view of both the frequency and the dissipation shifts.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Researcher 7 25%
Student > Master 3 11%
Student > Bachelor 1 4%
Other 1 4%
Other 1 4%
Unknown 6 21%
Readers by discipline Count As %
Engineering 9 32%
Materials Science 3 11%
Physics and Astronomy 3 11%
Biochemistry, Genetics and Molecular Biology 2 7%
Agricultural and Biological Sciences 2 7%
Other 1 4%
Unknown 8 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2012.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Biosensors & Bioelectronics
#2,208
of 6,847 outputs
Outputs of similar age
#37,824
of 106,682 outputs
Outputs of similar age from Biosensors & Bioelectronics
#16
of 46 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,847 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,682 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.