| Title |
The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines
|
|---|---|
| Published in |
NeuroMolecular Medicine, January 2002
|
| DOI | 10.1385/nmm:2:1:61 |
| Pubmed ID | |
| Authors |
Stacie D. Grossman, Linda C. Hsieh-Wilson, Patrick B. Allen, Angus C. Nairn, Paul Greengard |
| Abstract |
Spinophilin is enriched in dendritic spines, small protrusions of the postsynaptic membrane along the length of the dendrite that contain the majority of excitatory synapses. Spinophilin binds to protein phosphatase 1 with high affinity and targets it to dendritic spines, therefore placing it in proximity to regulate glutamate receptor activity. Spinophilin also binds to and bundles f-actin, the main cytoskeletal constituent of dendritic spines, and may therefore serve to regulate the structure of the synapse. In this study, we sought to determine the structural basis for the targeting of spinophilin to dendritic spines. Our results show that the actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 28% |
| Professor > Associate Professor | 4 | 16% |
| Researcher | 4 | 16% |
| Other | 2 | 8% |
| Professor | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 5 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 36% |
| Neuroscience | 7 | 28% |
| Computer Science | 2 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Unknown | 6 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from NeuroMolecular Medicine
#197
of 478 outputs
Outputs of similar age
#32,444
of 130,776 outputs
Outputs of similar age from NeuroMolecular Medicine
#8
of 17 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 478 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.