| Title |
HuR and mRNA stability
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, February 2001
|
| DOI | 10.1007/pl00000854 |
| Pubmed ID | |
| Authors |
C. M. Brennan, J. A. Steitz* |
| Abstract |
An important mechanism of posttranscriptional gene regulation in mammalian cells is the rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in their 3' untranslated regions. HuR, a ubiquitously expressed member of the Hu family of RNA-binding proteins related to Drosophila ELAV, selectively binds AREs and stabilizes ARE-containing mRNAs when overexpressed in cultured cells. This review discusses mRNA decay as a general form of gene regulation, decay signaled by AREs, and the role of HuR and its Hu-family relatives in antagonizing this mRNA degradation pathway. The influence of newly identified protein ligands to HuR on HuR function in both normal and stressed cells may explain how ARE-mediated mRNA decay is regulated in response to environmental change. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 357 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 2% |
| Canada | 4 | 1% |
| Austria | 3 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Russia | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 335 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 94 | 26% |
| Researcher | 60 | 17% |
| Student > Master | 44 | 12% |
| Student > Bachelor | 35 | 10% |
| Student > Doctoral Student | 19 | 5% |
| Other | 48 | 13% |
| Unknown | 57 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 136 | 38% |
| Biochemistry, Genetics and Molecular Biology | 88 | 25% |
| Medicine and Dentistry | 24 | 7% |
| Chemistry | 10 | 3% |
| Immunology and Microbiology | 8 | 2% |
| Other | 23 | 6% |
| Unknown | 68 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2023.
All research outputs
#2,759,955
of 25,374,647 outputs
Outputs from Cellular and Molecular Life Sciences
#405
of 5,877 outputs
Outputs of similar age
#4,477
of 113,958 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#1
of 14 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,958 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.