| Title |
Expression and Distribution of Dopamine Transporter in Cardiac Tissues of the Guinea Pig
|
|---|---|
| Published in |
Neurochemical Research, December 2010
|
| DOI | 10.1007/s11064-010-0344-7 |
| Pubmed ID | |
| Authors |
Alejandro Reynoso Palomar, Berenice Navarrete Larios, Victoria Chagoya De Sánchez, Lidia Martínez Pérez, Fidel De La Cruz López, Gonzalo Flores, Maria de Jesús Gómez-Villalobos |
| Abstract |
Dopamine transporter (DAT) is a membrane protein that it is a marker for dopaminergic neurons. In the present work, throught Western blot and autoradiographic studies with a selective ligand for DAT ([(3)H] WIN-35428) and noradrenaline transporter (NET) ([(3)H] Nisoxetine), we search the expression and distribution of DAT in comparison with NET, in cardiac tissue of guinea pig in order to support the presence of dopaminergic nerve cells into the heart. Expression of DAT, and NET were evidenced by a bands of 75 and 54 kDa, respectively in the heart. Binding for DAT and NET were found in the four cardiac chambers. However, DAT show heterogeneous distribution with binding in right atria and in both ventricles, whereas NET show homogenous distribution in the four cardiac chambers. The results show the expression of DAT in cardiac tissues with a different distribution compared with NET, being an evidence for the presence of dopaminergic nerve cells into the heart. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Lecturer > Senior Lecturer | 1 | 10% |
| Student > Bachelor | 1 | 10% |
| Other | 1 | 10% |
| Other | 2 | 20% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 40% |
| Nursing and Health Professions | 2 | 20% |
| Neuroscience | 1 | 10% |
| Agricultural and Biological Sciences | 1 | 10% |
| Unknown | 2 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2014.
All research outputs
#7,209,953
of 22,789,076 outputs
Outputs from Neurochemical Research
#564
of 2,095 outputs
Outputs of similar age
#53,172
of 182,177 outputs
Outputs of similar age from Neurochemical Research
#10
of 20 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,095 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 182,177 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.