| Title |
Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice
|
|---|---|
| Published in |
Genes & Nutrition, February 2009
|
| DOI | 10.1007/s12263-009-0110-0 |
| Pubmed ID | |
| Authors |
Alessandro Bartolomucci, Elena Bresciani, Ilaria Bulgarelli, Antonello E. Rigamonti, Tiziana Pascucci, Andrea Levi, Roberta Possenti, Antonio Torsello, Vittorio Locatelli, Eugenio E. Muller, Anna Moles |
| Abstract |
The vgf gene regulates energy homeostasis and the VGF-derived peptide TLQP-21 centrally exerts catabolic effects in mice and hamsters. Here, we investigate the effect of chronic intracerebroventricular (icv) injection of TLQP-21 in mice fed high fat diet (HFD). Fast weight-gaining mice injected with the peptide or cerebrospinal fluid were selected for physiological, endocrine, and molecular analysis. TLQP-21 selectively inhibited the increase in body weight and epididymal white adipose tissue (eWAT) weight induced by HFD in control animals despite both groups having a similar degree of hyperphagia. TLQP-21 normalized the increase in leptin and decrease in ghrelin while increasing epinephrine and epinephrine/norepinephrine ratio when compared to values in controls. Finally, HFD-TLQP-21 mice showed a selective increase of eWAT beta3-adrenergic receptor mRNA. Peroxisome-proliferator-activated-receptor-delta and hormone-sensing-lipase mRNA were also upregulated. In conclusion, chronic icv infusion of TLQP-21 prevented the early phase of diet-induced obesity despite overfeeding. These effects were paralleled by activation of catabolic pathways within the eWAT. Our results further support a role for TLQP-21 as a catabolic neuropeptide. |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 5% |
| Brazil | 1 | 5% |
| Unknown | 20 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 23% |
| Professor > Associate Professor | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Doctoral Student | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 3 | 14% |
| Unknown | 4 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 32% |
| Neuroscience | 4 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Social Sciences | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 5 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2013.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Genes & Nutrition
#143
of 388 outputs
Outputs of similar age
#32,788
of 93,165 outputs
Outputs of similar age from Genes & Nutrition
#4
of 5 outputs
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