| Title |
Expression of pp32 gene family members in breast cancer
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, July 2001
|
| DOI | 10.1023/a:1017919507109 |
| Pubmed ID | |
| Authors |
ShriHari S. Kadkol, Gamal Abou El Naga, Jonathan R. Brody, Jining Bai, Yuri Gusev, William C. Dooley, Gary R. Pasternack |
| Abstract |
The pp32 gene family consists of at least three closely related members, pp32, pp32r1 and pp32r2. In spite of a high degree of identity at the nucleotide level, pp32 functionally behaves as a tumor suppressor where as pp32r1 and pp32r2 are pro-oncogenic. The purpose of this pilot study was to determine pp32-related expression and whether alternative gene use among the pp32 family members occurred in human breast cancer. As a first step, in situ hybridization with a riboprobe capable of hybridizing with all the three members showed abundant pp32-related mRNA in benign ducts and acini and in infiltrating ductal carcinomas. A total of 100/102 cases were positive. Further, a detailed molecular analysis by RT-PCR, cloning, and sequencing was performed in five frozen infiltrating breast carcinomas and matched benign breast tissues. Oncogenic pp32r1 (5/5) and pp32r2 (3/5) expression was observed in carcinomas where as benign breast tissues expressed pp32. 4/5 carcinomas continued to express pp32 but one was devoid of pp32 expression. These results suggest that alternative expression of pp32 family members may be common in human breast cancer and the analysis of the profile of pp32-related expression might be helpful in understanding the role of these genes in breast cancer pathogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 50% |
| Professor | 1 | 13% |
| Other | 1 | 13% |
| Student > Master | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 38% |
| Biochemistry, Genetics and Molecular Biology | 2 | 25% |
| Medicine and Dentistry | 1 | 13% |
| Neuroscience | 1 | 13% |
| Engineering | 1 | 13% |
| Other | 0 | 0% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Breast Cancer Research and Treatment
#1,658
of 4,655 outputs
Outputs of similar age
#12,832
of 38,927 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#2
of 10 outputs
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