| Title |
In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light
|
|---|---|
| Published in |
Molecular Imaging and Biology, May 2011
|
| DOI | 10.1007/s11307-011-0489-z |
| Pubmed ID | |
| Authors |
Chongzhao Ran, Zhaoda Zhang, Jacob Hooker, Anna Moore |
| Abstract |
The poor tissue penetration of visible light has been a major barrier for optical imaging, photoactivatable conversions, and photodynamic therapy for in vivo targets with depths beyond 10 mm. In this report, as a proof-of-concept, we demonstrated that a positron emission tomography (PET) radiotracer, 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)FDG), could be used as an alternative light source for photoactivation. We utilized (18)FDG, which is a metabolic activity-based PET probe, as a source of light to photoactivate caged luciferin in a breast cancer animal model expressing luciferase. Bioluminescence produced from luciferin allowed for the real-time monitoring of Cherenkov radiation-promoted uncaging of the substrate. The proposed method may provide a very important option for in vivo photoactivation, in particular for activation of photosensitizers for photodynamic therapy and eventually for combining radioisotope therapy and photodynamic therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 4% |
| United Kingdom | 1 | 1% |
| Austria | 1 | 1% |
| Denmark | 1 | 1% |
| Iran, Islamic Republic of | 1 | 1% |
| Unknown | 83 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 29% |
| Student > Ph. D. Student | 22 | 24% |
| Student > Master | 10 | 11% |
| Other | 6 | 7% |
| Student > Bachelor | 5 | 5% |
| Other | 11 | 12% |
| Unknown | 11 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 17 | 19% |
| Agricultural and Biological Sciences | 13 | 14% |
| Medicine and Dentistry | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Physics and Astronomy | 6 | 7% |
| Other | 21 | 23% |
| Unknown | 16 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2017.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Molecular Imaging and Biology
#244
of 837 outputs
Outputs of similar age
#45,513
of 122,075 outputs
Outputs of similar age from Molecular Imaging and Biology
#3
of 8 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 837 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,075 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.