| Title |
The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, September 2011
|
| DOI | 10.1007/s00424-011-1028-0 |
| Pubmed ID | |
| Authors |
Eileen Pernot, Sara Terryn, Siew Chiat Cheong, Nicolas Markadieu, Sylvie Janas, Marianne Blockmans, Monique Jacoby, Valérie Pouillon, Stéphanie Gayral, Bernard C. Rossier, Renaud Beauwens, Christophe Erneux, Olivier Devuyst, Stéphane Schurmans |
| Abstract |
Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. In this study, we explored the function of this inositol 5-phosphatase in mice and cells overexpressing the 42-kDa mouse Inpp5k protein. Inpp5k transgenic mice present defects in water metabolism characterized by a reduced plasma osmolality at baseline, a delayed urinary water excretion following a water load, and an increased acute response to vasopressin. These defects are associated with the expression of the Inpp5k transgene in renal collecting ducts and with alterations in the arginine vasopressin/aquaporin-2 signalling pathway in this tubular segment. Analysis in a mouse collecting duct mCCD cell line revealed that Inpp5k overexpression leads to increased expression of the arginine vasopressin receptor type 2 and increased cAMP response to arginine vasopressin, providing a basis for increased aquaporin-2 expression and plasma membrane localization with increased osmotically induced water transport. Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts. |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 5% |
| Unknown | 21 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 36% |
| Researcher | 5 | 23% |
| Student > Master | 4 | 18% |
| Professor | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Other | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 50% |
| Agricultural and Biological Sciences | 4 | 18% |
| Medicine and Dentistry | 4 | 18% |
| Environmental Science | 1 | 5% |
| Neuroscience | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 1 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2012.
All research outputs
#7,855,444
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#476
of 1,973 outputs
Outputs of similar age
#45,735
of 132,709 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#7
of 11 outputs
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