| Title |
Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases
|
|---|---|
| Published in |
Cell and Tissue Research, October 1998
|
| DOI | 10.1007/s004410051181 |
| Pubmed ID | |
| Authors |
H. W. Heid, R. Moll, I. Schwetlick, Hans-Richard Rackwitz, Thomas W. Keenan |
| Abstract |
We report the human DNA and protein sequence of adipophilin and its association with the surface of lipid droplets. The amino acid sequence of human adipophilin has been determined by using cDNA clones from several tissues and confirmed by the reverse transcription/polymerase chain reaction method and Edman sequencing. The open reading frame of adipophilin encodes a polypeptide with a calculated molecular weight of 48.1 kDa and an isoelectric point of 6.72. By immunofluorescence and electron-microscopic localization with newly raised specific poly- and monoclonal antibodies, we show that this protein is not restricted to adipocytes as previously indicated by studies of the mouse homologous protein, adipose-differentiation-related protein. Adipophilin occurs in a wide range of cultured cell lines, including fibroblasts and endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. Our results reveal adipophilin as a possible new marker for the identification of specialized differentiated cells containing lipid droplets and for diseases associated with fat-accumulating cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Ireland | 1 | 1% |
| Brazil | 1 | 1% |
| Austria | 1 | 1% |
| Czechia | 1 | 1% |
| Finland | 1 | 1% |
| Unknown | 92 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 23% |
| Researcher | 19 | 19% |
| Student > Master | 8 | 8% |
| Student > Doctoral Student | 8 | 8% |
| Student > Bachelor | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 38% |
| Biochemistry, Genetics and Molecular Biology | 19 | 19% |
| Medicine and Dentistry | 12 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Unspecified | 1 | 1% |
| Other | 4 | 4% |
| Unknown | 23 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2014.
All research outputs
#5,611,796
of 26,017,215 outputs
Outputs from Cell and Tissue Research
#297
of 2,321 outputs
Outputs of similar age
#5,061
of 32,932 outputs
Outputs of similar age from Cell and Tissue Research
#1
of 7 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,321 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 32,932 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them