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Human KLF17 is a new member of the Sp/KLF family of transcription factors

Overview of attention for article published in Genomics, February 2006
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

patent
6 patents
wikipedia
5 Wikipedia pages

Citations

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98 Dimensions

Readers on

mendeley
48 Mendeley
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Title
Human KLF17 is a new member of the Sp/KLF family of transcription factors
Published in
Genomics, February 2006
DOI 10.1016/j.ygeno.2005.12.011
Pubmed ID
Authors

Jane van Vliet, Linda A. Crofts, Kate G.R. Quinlan, Robert Czolij, Andrew C. Perkins, Merlin Crossley

Abstract

The Sp/KLF transcription factors perform a variety of biological functions, but are related in that they bind GC-box and CACCC-box sequences in DNA via a highly conserved DNA-binding domain. A database homology search, using the zinc finger DNA-binding domain characteristic of the family, has identified human KLF17 as a new family member that is most closely related to KLFs 1-8 and 12. KLF17 appears to be the human orthologue of the previously reported mouse gene, zinc finger protein 393 (Zfp393), although it has diverged significantly. The DNA-binding domain is the most conserved region, suggesting that both the murine and the human forms recognize the same binding sites in DNA and may retain similar functions. We show that human KLF17 can bind G/C-rich sites via its zinc fingers and is able to activate transcription from CACCC-box elements. This is the first report of the DNA-binding characteristics and transactivation activity of human KLF17, which, together with the homology it displays to other KLF proteins, put it in the Sp/KLF family.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 4%
Canada 1 2%
Unknown 45 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 19%
Student > Ph. D. Student 8 17%
Student > Master 7 15%
Student > Bachelor 6 13%
Professor > Associate Professor 3 6%
Other 9 19%
Unknown 6 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 33%
Biochemistry, Genetics and Molecular Biology 15 31%
Medicine and Dentistry 7 15%
Unspecified 2 4%
Social Sciences 1 2%
Other 1 2%
Unknown 6 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2023.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Genomics
#859
of 5,922 outputs
Outputs of similar age
#21,905
of 171,112 outputs
Outputs of similar age from Genomics
#6
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,922 research outputs from this source. They receive a mean Attention Score of 4.5. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.