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Mendeley readers
Attention Score in Context
| Title |
HIV1 Vpr Arrests the Cell Cycle by Recruiting DCAF1/VprBP, a Receptor of the Cul4-DDB1 Ubiquitin Ligase
|
|---|---|
| Published in |
Cell Cycle, October 2014
|
| DOI | 10.4161/cc.6.2.3732 |
| Pubmed ID | |
| Authors |
Erwann Le Rouzic, Nadia Belaïdouni, Emilie Estrabaud, Marina Morel, Jean-Christophe Rain, Catherine Transy, Florence Margottin-Goguet |
| Abstract |
How the HIV1 Vpr protein initiates the host cell response leading to cell cycle arrest in G(2) has remained unknown. Here, we show that recruitment of DCAF1/VprBP by Vpr is essential for its cytostatic activity, which can be abolished either by single mutations of Vpr that impair DCAF1 binding, or by siRNA-mediated silencing of DCAF1. Furthermore, DCAF1 bridges Vpr to DDB1, a core subunit of Cul4 ubiquitin ligases. Altogether these results point to a mechanism where Vpr triggers G(2) arrest by hijacking the Cul4/DDB1(DCAF1) ubiquitin ligase. We further show that, Vpx, a non-cytostatic Vpr-related protein acquired by HIV2 and SIV, also binds DCAF1 through a conserved motif. Thus, Vpr from HIV1 and Vpx from SIV recruit DCAF1 with different physiological outcomes for the host cell. This in turn suggests that both proteins have evolved to preserve interaction with the same Cul4 ubiquitin ligase while diverging in the recognition of host substrates targeted for proteasomal degradation. |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 39% |
| Researcher | 12 | 14% |
| Student > Master | 12 | 14% |
| Student > Bachelor | 6 | 7% |
| Professor > Associate Professor | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 7 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 35% |
| Biochemistry, Genetics and Molecular Biology | 24 | 29% |
| Immunology and Microbiology | 13 | 15% |
| Medicine and Dentistry | 6 | 7% |
| Business, Management and Accounting | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 7 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#4,696,673
of 22,789,076 outputs
Outputs from Cell Cycle
#369
of 3,684 outputs
Outputs of similar age
#55,157
of 260,394 outputs
Outputs of similar age from Cell Cycle
#170
of 1,254 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,684 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,394 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1,254 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.