Title |
TGF-β induces the expression of SAP30L, a novel nuclear protein
|
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Published in |
BMC Genomics, December 2003
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DOI | 10.1186/1471-2164-4-53 |
Pubmed ID | |
Authors |
Katri Lindfors, Keijo M Viiri, Marjo Niittynen, Taisto YK Heinonen, Markku Mäki, Heikki Kainulainen |
Abstract |
We have previously set up an in vitro mesenchymal-epithelial cell co-culture model which mimics the intestinal crypt villus axis biology in terms of epithelial cell differentiation. In this model the fibroblast-induced epithelial cell differentiation from secretory crypt cells to absorptive enterocytes is mediated via transforming growth factor-beta (TGF-beta), the major inhibitory regulator of epithelial cell proliferation known to induce differentiation in intestinal epithelial cells. The aim of this study was to identify novel genes whose products would play a role in this TGF-beta-induced differentiation. |
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