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Mendeley readers
Attention Score in Context
| Title |
Human Mitochondrial Thioredoxin INVOLVEMENT IN MITOCHONDRIAL MEMBRANE POTENTIAL AND CELL DEATH*
|
|---|---|
| Published in |
Journal of Biological Chemistry, June 2002
|
| DOI | 10.1074/jbc.m203036200 |
| Pubmed ID | |
| Authors |
Anastasios E. Damdimopoulos, Antonio Miranda-Vizuete, Markku Pelto-Huikko, Jan-Åke Gustafsson, Giannis Spyrou |
| Abstract |
Thioredoxins (Trx) are a class of small multifunctional redox-active proteins found in all organisms. Recently, we reported the cloning of a mitochondrial thioredoxin, Trx2, from rat heart. To investigate the biological role of Trx2 we have isolated the human homologue, hTrx2, and generated HEK-293 cells overexpressing Trx2 (HEK-Trx2). Here, we show that HEK-Trx2 cells are more resistant toward etoposide. In addition, HEK-Trx2 are more sensitive toward rotenone, an inhibitor of complex I of the respiratory chain. Finally, overexpression of Trx2 confers an increase in mitochondrial membrane potential, DeltaPsi(m). Treatment with oligomycin could both reverse the effect of rotenone and decrease the membrane potential suggesting that Trx2 interferes with the activity of ATP synthase. Taken together, these results suggest that Trx2 interacts with specific components of the mitochondrial respiratory chain and plays an important role in the regulation of the mitochondrial membrane potential. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 2% |
| France | 1 | 2% |
| Singapore | 1 | 2% |
| Spain | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 41 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 26% |
| Student > Ph. D. Student | 11 | 24% |
| Student > Master | 5 | 11% |
| Student > Bachelor | 4 | 9% |
| Student > Doctoral Student | 4 | 9% |
| Other | 7 | 15% |
| Unknown | 3 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 46% |
| Biochemistry, Genetics and Molecular Biology | 15 | 33% |
| Medicine and Dentistry | 2 | 4% |
| Neuroscience | 2 | 4% |
| Environmental Science | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 4 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#5,446,629
of 25,374,647 outputs
Outputs from Journal of Biological Chemistry
#13,967
of 85,241 outputs
Outputs of similar age
#8,505
of 48,128 outputs
Outputs of similar age from Journal of Biological Chemistry
#157
of 908 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,241 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 48,128 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 908 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.