Title |
Prediction of Subcellular Localization of Apoptosis Protein Using Chou’s Pseudo Amino Acid Composition
|
---|---|
Published in |
Acta Biotheoretica, January 2009
|
DOI | 10.1007/s10441-008-9067-4 |
Pubmed ID | |
Authors |
Hao Lin, Hao Wang, Hui Ding, Ying-Li Chen, Qian-Zhong Li |
Abstract |
Apoptosis proteins play an essential role in regulating a balance between cell proliferation and death. The successful prediction of subcellular localization of apoptosis proteins directly from primary sequence is much benefited to understand programmed cell death and drug discovery. In this paper, by use of Chou's pseudo amino acid composition (PseAAC), a total of 317 apoptosis proteins are predicted by support vector machine (SVM). The jackknife cross-validation is applied to test predictive capability of proposed method. The predictive results show that overall prediction accuracy is 91.1% which is higher than previous methods. Furthermore, another dataset containing 98 apoptosis proteins is examined by proposed method. The overall predicted successful rate is 92.9%. |
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Demographic breakdown
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