Title |
Seventy-five years of Resochin® in the fight against malaria
|
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Published in |
Parasitology Research, July 2009
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DOI | 10.1007/s00436-009-1524-8 |
Pubmed ID | |
Authors |
Markus Jensen, Heinz Mehlhorn |
Abstract |
The four different forms of human malaria have threatened humanity since time immemorial and to this day, they exact a death toll of one to three million people annually. Synthetic anti-malarial agents have been in development since early 1900. Perhaps the most successful and widely used drug, Resochin (chloroquine), was discovered 75 years ago; for a long time, it was the drug of choice and to this day, it is still used in many regions of the world as a reliable treatment against simpler forms of malaria. In regions where it has not been in use against malaria tropica for quite some time due to the development of resistances, it has regained some of its efficacy. This review traces the discovery and the mechanism of action of this substance, illustrates the significance of malaria today, and underlines the need for controlled and reliable therapeutic measures. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
New Zealand | 1 | <1% |
Lithuania | 1 | <1% |
Kenya | 1 | <1% |
Unknown | 315 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 6% |
Researcher | 14 | 4% |
Student > Master | 12 | 4% |
Other | 6 | 2% |
Student > Bachelor | 5 | 2% |
Other | 15 | 5% |
Unknown | 248 | 78% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 5% |
Medicine and Dentistry | 10 | 3% |
Social Sciences | 9 | 3% |
Biochemistry, Genetics and Molecular Biology | 8 | 3% |
Chemistry | 6 | 2% |
Other | 18 | 6% |
Unknown | 252 | 79% |