| Title |
High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin
|
|---|---|
| Published in |
Chromosome Research, February 1997
|
| DOI | 10.1023/a:1018437301461 |
| Pubmed ID | |
| Authors |
Birgitta Gla¨ser, Thomas Hierl, Kay Taylor, Katrin Schiebel, Sylvia Zeitler, Katia Papadopoullos, Gudrun Rappold, Werner Schempp |
| Abstract |
Genes within the differential region of the human Y chromosome do not recombine, and therefore the determination of their location depends on physical mapping. Yeast artificial chromosome (YAC) contigs spanning the euchromatic region of the human Y have become a powerful tool for the generation of an overlapping clone map. With this approach, however, complete physical mapping is difficult in Y euchromatic regions that are rich in repetitive sequences. We have, therefore, made use of the fluorescence in situ hybridization technique as an alternative strategy for physically mapping the PRKY and AMELY genes as well as the TSPY, RBM and DAZ gene families to human Y chromosomes in prometaphase and to extended Y chromatin in interphase. From our results, the following order of gene sequences in interval 3 of the short arm of the human Y chromosome is suggested: TSPY major with few RBM sequences interspersed-PRKY-AMELY-TSPY minor with few RBM sequences interspersed-cen. On the long arm, RBM sequences appear to be distributed over wide regions of intervals 5 and 6 with few TSPY sequences interspersed. Distal to an RBM signal cluster, a large cluster of DAZ signals is located with only a few DAZ and RBM signals overlapping in between the two clusters. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 13% |
| Unknown | 7 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 50% |
| Professor > Associate Professor | 2 | 25% |
| Professor | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 50% |
| Biochemistry, Genetics and Molecular Biology | 3 | 38% |
| Unknown | 1 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2019.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Chromosome Research
#169
of 536 outputs
Outputs of similar age
#20,408
of 93,667 outputs
Outputs of similar age from Chromosome Research
#2
of 7 outputs
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