| Title |
Single dose pharmacokinetics of fenspiride hydrochloride: phase I clinical trial
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, September 1993
|
| DOI | 10.1007/bf00315501 |
| Pubmed ID | |
| Authors |
B. Montes, M. Catalan, A. Roces, J. P. Jeanniot, J. M. Honorato |
| Abstract |
The absolute bioavailability of fenspiride has been studied in twelve healthy volunteers. It was administered IV and orally in single doses of 80 mg fenspiride hydrochloride according to a randomised crossover pattern. Following IV administration, the plasma clearance of fenspiride was about 184 ml.min-1, and its apparent volume of distribution was moderately large (215 l). When given orally as a tablet, fenspiride exhibited fairly slow ab- sorption; the maximum plasma concentration (206 ng.ml-1) was achieved 6 h after administration. The absolute bioavailability was almost complete (90%). The tablet had slow release characteristics. The elimination half-life obtained from the plasma data was 14 to 16 h independent of the route of administration. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 50% |
| Professor > Associate Professor | 1 | 17% |
| Other | 1 | 17% |
| Student > Master | 1 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 50% |
| Medicine and Dentistry | 3 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2022.
All research outputs
#7,613,813
of 23,213,531 outputs
Outputs from European Journal of Clinical Pharmacology
#848
of 2,583 outputs
Outputs of similar age
#5,912
of 20,264 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#3
of 10 outputs
Altmetric has tracked 23,213,531 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,583 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
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