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Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems

Overview of attention for article published in Developmental Dynamics, November 2006
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Title
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems
Published in
Developmental Dynamics, November 2006
DOI 10.1002/dvdy.21015
Pubmed ID
Authors

David J. Pennisi, Lorine Wilkinson, Gabriel Kolle, Michael L. Sohaskey, Kevin Gillinder, Michael J. Piper, John W. McAvoy, Frank J. Lovicu, Melissa H. Little

Abstract

Crim1 is a transmembrane protein, containing six vWF-C type cysteine-rich repeats, that tethers growth factors to the cell surface. A mouse line, KST264, generated in a LacZ insertion mutagenesis gene-trap screen, was examined to elucidate Crim1 function in development. We showed that Crim1(KST264/KST264) mice were not null for Crim1 due to the production of a shortened protein isoform. These mice are likely to represent an effective hypomorph or a dominant-negative for Crim1. Transgene expression recapitulated known Crim1 expression in lens, brain, and limb, but also revealed expression in the smooth muscle cells of the developing heart and renal vasculature, developing cartilage, mature ovary and detrusor of the bladder. Transgene expression was also observed in glomerular epithelial cells, podocytes, mesangial cells, and urothelium in the kidney. Crim1(KST264/KST264) mice displayed perinatal lethality, syndactyly, eye, and kidney abnormalities. The severe and complex phenotype observed in Crim1(KST264/KST264) mice highlights the importance of Crim1 in numerous aspects of organogenesis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
United States 1 3%
Australia 1 3%
Unknown 27 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 30%
Professor 7 23%
Student > Bachelor 4 13%
Student > Doctoral Student 4 13%
Student > Ph. D. Student 2 7%
Other 3 10%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 57%
Biochemistry, Genetics and Molecular Biology 9 30%
Medicine and Dentistry 2 7%
Neuroscience 1 3%
Unknown 1 3%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,204,344
of 24,583,586 outputs
Outputs from Developmental Dynamics
#710
of 2,095 outputs
Outputs of similar age
#26,364
of 75,388 outputs
Outputs of similar age from Developmental Dynamics
#5
of 13 outputs
Altmetric has tracked 24,583,586 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,095 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,388 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.