| Title |
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility
|
|---|---|
| Published in |
Rheumatology International, January 2008
|
| DOI | 10.1007/s00296-008-0525-8 |
| Pubmed ID | |
| Authors |
Berna Tander, Sezgin Gunes, Omer Boke, Gamze Alayli, Nurten Kara, Hasan Bagci, Ferhan Canturk |
| Abstract |
Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS. |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Croatia | 1 | 2% |
| Unknown | 61 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Researcher | 8 | 13% |
| Student > Bachelor | 8 | 13% |
| Student > Master | 7 | 11% |
| Professor > Associate Professor | 5 | 8% |
| Other | 12 | 19% |
| Unknown | 11 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 30% |
| Psychology | 7 | 11% |
| Nursing and Health Professions | 6 | 10% |
| Agricultural and Biological Sciences | 6 | 10% |
| Neuroscience | 3 | 5% |
| Other | 9 | 14% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2008.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Rheumatology International
#802
of 2,180 outputs
Outputs of similar age
#41,913
of 156,836 outputs
Outputs of similar age from Rheumatology International
#3
of 6 outputs
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