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Survival and Quality of Life Impact of a Risk-based Allocation Algorithm for Deceased Donor Kidney Transplantation

Overview of attention for article published in Transplantation, September 2018
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  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
Survival and Quality of Life Impact of a Risk-based Allocation Algorithm for Deceased Donor Kidney Transplantation
Published in
Transplantation, September 2018
DOI 10.1097/tp.0000000000002144
Pubmed ID
Authors

Vaishnavi Calisa, Jonathan C Craig, Kirsten Howard, Martin Howell, Stephen Alexander, Steven J Chadban, Philip Clayton, Wai H Lim, John Kanellis, Kate Wyburn, David W Johnson, Stephen P McDonald, Helen Opdam, Jeremy R Chapman, Jean Yang, Germaine Wong

Abstract

To determine the incremental gains in graft and patient survival under a risk-based, deceased donor kidney allocation compared to the current Australian algorithm. Risk-based matching algorithms were applied to first graft, kidney only recipients (n=7513) transplanted in Australia between 1994 and 2013. Probabilistic models were used to compare the waiting time, life and quality-adjusted life years and graft years between the 8 risk-based allocation strategies against current practice. Compared to current practice, KDRI-EPTS matching of the lowest 20% of scores reduced median waiting time by 0.64 years (95% CI: 0.52-0.73) for recipients aged ≤ 30 years, but increased waiting time by 0.94 years (95% CI: 0.79 - 1.09) for recipients aged > 60 years. Among all age groups, the greatest gains occurred if KDRI-EPTS matching of the lowest 30% of scores was used, incurring a median overall gain of 0.63 (95% CI: 0.03-1.25) life years and 0.78 (95% CI: 0.30 - 1.26) graft years compared to current practice. A median gain in survival of 1.91 years for younger recipients (aged 30-45 years) was offset by a median reduction in survival (by 0.95 life years) among the older recipients. Prioritisation of lower quality donor kidneys for older candidates reduced the waiting time for recipients aged > 45 years, but no changes in graft and patient survivals were observed. Risk-based matching engendered a moderate, overall increase in graft and patient survival, accrued through benefits for recipients aged ≤ 45 years but disadvantage to recipients aged > 60 years.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 4 15%
Student > Master 3 12%
Other 2 8%
Researcher 2 8%
Student > Postgraduate 2 8%
Other 6 23%
Unknown 7 27%
Readers by discipline Count As %
Medicine and Dentistry 13 50%
Unspecified 4 15%
Mathematics 2 8%
Agricultural and Biological Sciences 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 0 0%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2019.
All research outputs
#14,605,790
of 25,382,440 outputs
Outputs from Transplantation
#4,709
of 7,577 outputs
Outputs of similar age
#171,252
of 345,713 outputs
Outputs of similar age from Transplantation
#22
of 60 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,713 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.