| Title |
Novel disposable biochip platform employing supercritical angle fluorescence for enhanced fluorescence collection
|
|---|---|
| Published in |
Biomedical Microdevices, May 2011
|
| DOI | 10.1007/s10544-011-9546-2 |
| Pubmed ID | |
| Authors |
Duncan Hill, Barry McDonnell, Stephen Hearty, Lourdes Basabe-Desmonts, Robert Blue, Michal Trnavsky, Colm McAtamney, Richard O’Kennedy, Brian D. MacCraith |
| Abstract |
This paper presents an overview of development of a novel disposable plastic biochip for multiplexed clinical diagnostic applications. The disposable biochip is manufactured using a low-cost, rapid turn- around injection moulding process and consists of nine parabolic elements on a planar substrate. The optical elements are based on supercritical angle fluorescence (SAF) which provides substantial enhancement of the fluorescence collection efficiency but also confines the fluorescence detection volume strictly to the immediate proximity of the biochip surface, thereby having the potential to discriminate against background fluorescence from the analyte solution. An optical reader is also described that enables interrogation and fluorescence collection from the nine optical elements on the chip. The sensitivity of the system was determined with a biotin-avidin assay while its clinical utility was demonstrated in an assay for C-reactive protein (CRP), an inflammation marker. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 33% |
| Student > Ph. D. Student | 6 | 29% |
| Other | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Physics and Astronomy | 5 | 24% |
| Agricultural and Biological Sciences | 4 | 19% |
| Engineering | 3 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 10% |
| Sports and Recreations | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 3 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2020.
All research outputs
#3,272,447
of 22,789,076 outputs
Outputs from Biomedical Microdevices
#47
of 747 outputs
Outputs of similar age
#15,825
of 109,858 outputs
Outputs of similar age from Biomedical Microdevices
#2
of 13 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 747 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,858 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.