| Title |
Recent Genetics and Epigenetics Approaches to PTSD
|
|---|---|
| Published in |
Current Psychiatry Reports, April 2018
|
| DOI | 10.1007/s11920-018-0898-7 |
| Pubmed ID | |
| Authors |
Nikolaos P. Daskalakis, Chuda M. Rijal, Christopher King, Laura M. Huckins, Kerry J. Ressler |
| Abstract |
Following a life-threatening traumatic exposure, about 10% of those exposed are at considerable risk for developing posttraumatic stress disorder (PTSD), a severe and disabling syndrome characterized by uncontrollable intrusive memories, nightmares, avoidance behaviors, and hyperarousal in addition to impaired cognition and negative emotion symptoms. This review will explore recent genetic and epigenetic approaches to PTSD that explain some of the differential risk following trauma exposure. A substantial portion of the variance explaining differential risk responses to trauma exposure may be explained by differential inherited and acquired genetic and epigenetic risk. This biological risk is complemented by alterations in the functional regulation of genes via environmentally induced epigenetic changes, including prior childhood and adult trauma exposure. This review will cover recent findings from large-scale genome-wide association studies as well as newer epigenome-wide studies. We will also discuss future "phenome-wide" studies utilizing electronic medical records as well as targeted genetic studies focusing on mechanistic ways in which specific genetic or epigenetic alterations regulate the biological risk for PTSD. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 38% |
| United States | 2 | 15% |
| Australia | 1 | 8% |
| Ireland | 1 | 8% |
| Unknown | 4 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 62% |
| Scientists | 3 | 23% |
| Practitioners (doctors, other healthcare professionals) | 2 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 177 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 26 | 15% |
| Student > Ph. D. Student | 22 | 12% |
| Student > Master | 18 | 10% |
| Researcher | 13 | 7% |
| Student > Doctoral Student | 12 | 7% |
| Other | 23 | 13% |
| Unknown | 63 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 12% |
| Psychology | 20 | 11% |
| Medicine and Dentistry | 20 | 11% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Agricultural and Biological Sciences | 7 | 4% |
| Other | 23 | 13% |
| Unknown | 69 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2022.
All research outputs
#1,945,047
of 23,322,966 outputs
Outputs from Current Psychiatry Reports
#224
of 1,207 outputs
Outputs of similar age
#44,250
of 330,474 outputs
Outputs of similar age from Current Psychiatry Reports
#6
of 29 outputs
Altmetric has tracked 23,322,966 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,207 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 81% of its peers.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.