| Title |
The AP-2 family of transcription factors
|
|---|---|
| Published in |
Genome Biology, December 2005
|
| DOI | 10.1186/gb-2005-6-13-246 |
| Pubmed ID | |
| Authors |
Dawid Eckert, Sandra Buhl, Susanne Weber, Richard Jäger, Hubert Schorle |
| Abstract |
The AP-2 family of transcription factors consists of five different proteins in humans and mice: AP-2alpha, AP-2beta, AP-2gamma, AP-2delta and AP-2epsilon. Frogs and fish have known orthologs of some but not all of these proteins, and homologs of the family are also found in protochordates, insects and nematodes. The proteins have a characteristic helix-span-helix motif at the carboxyl terminus, which, together with a central basic region, mediates dimerization and DNA binding. The amino terminus contains the transactivation domain. AP-2 proteins are first expressed in primitive ectoderm of invertebrates and vertebrates; in vertebrates, they are also expressed in the emerging neural-crest cells, and AP-2alpha-/- animals have impairments in neural-crest-derived facial structures. AP-2beta is indispensable for kidney development and AP-2gamma is necessary for the formation of trophectoderm cells shortly after implantation; AP-2alpha and AP-2gamma levels are elevated in human mammary carcinoma and seminoma. The general functions of the family appear to be the cell-type-specific stimulation of proliferation and the suppression of terminal differentiation during embryonic development. |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Spain | 2 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| Ukraine | 1 | <1% |
| Italy | 1 | <1% |
| Argentina | 1 | <1% |
| Lithuania | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 237 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 24% |
| Researcher | 53 | 21% |
| Student > Master | 31 | 12% |
| Student > Bachelor | 24 | 9% |
| Professor > Associate Professor | 11 | 4% |
| Other | 38 | 15% |
| Unknown | 37 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 113 | 44% |
| Biochemistry, Genetics and Molecular Biology | 62 | 24% |
| Medicine and Dentistry | 13 | 5% |
| Neuroscience | 10 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 1% |
| Other | 9 | 4% |
| Unknown | 44 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2024.
All research outputs
#4,311,901
of 25,371,288 outputs
Outputs from Genome Biology
#2,680
of 4,467 outputs
Outputs of similar age
#17,537
of 173,491 outputs
Outputs of similar age from Genome Biology
#4
of 22 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,491 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.