Rationale Myeloid-derived suppressor cell (MDSC) expansion has been found to play a role in disease progression in cancer patients. However, the characteristics of MDSCs in lung cancer are poorly understood. Objectives We prospectively investigated MDSCs and inflammatory factors in tumor and peripheral blood samples from patients with resectable non-small cell lung cancer (NSCLC) and studied their correlations with the disease prognosis. Methods A complex analysis of MDSC subsets and inflammatory mediators was performed using flow cytometry and a Bio-Plex assay. Results A significant increase in the frequency of circulating monocytic (M)-MDSCs was observed in the NSCLC patients compared with the healthy donors (HDs). Moreover, the frequencies of M- and polymorphonuclear (PMN)-MDSCs were higher in tumors than in the peripheral blood of the same patients. This accumulation was associated with elevated concentrations of inflammatory mediators involved in MDSC migration to and activation in the tumor microenvironment. An analysis of the MDSC immunosuppressive pattern showed increased programmed death-ligand 1 (PD-L1) expression on circulating cells from patients compared with HDs. Tumor PMN-MDSCs displayed higher PD-L1 expression levels than the same cells in the peripheral blood. The frequency of C-C chemokine receptor 5 (CCR5) expression on circulating M-MDSCs was significantly higher in the patients than in the HDs. Clinical data analysis revealed negative correlations between recurrence-free survival and the frequencies of PMN-MDSCs and CCR5+ M-MDSCs in the circulation but not in tumors. Conclusion Our findings suggest that the level of MDSCs in the peripheral blood but not in tumor tissues predicts recurrence following surgery.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2020.
All research outputs
#9,232,848
of 34,411,289 outputs
Outputs from American Journal of Respiratory & Critical Care Medicine
#7,393
of 15,143 outputs
Outputs of similar age
#113,281
of 379,061 outputs
Outputs of similar age from American Journal of Respiratory & Critical Care Medicine
#75
of 153 outputs
Altmetric has tracked 34,411,289 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 15,143 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 379,061 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
