| Title |
Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery
|
|---|---|
| Published in |
Brain Structure and Function, January 2008
|
| DOI | 10.1007/s00429-007-0170-0 |
| Pubmed ID | |
| Authors |
Marc N. Gallay, Daniel Jeanmonod, Jian Liu, Anne Morel |
| Abstract |
Anatomical knowledge of the structures to be targeted and of the circuitry involved is crucial in stereotactic functional neurosurgery. The present study was undertaken in the context of surgical treatment of motor disorders such as essential tremor (ET) and Parkinson's disease (PD) to precisely determine the course and three-dimensional stereotactic localisation of the cerebellothalamic and pallidothalamic tracts in the human brain. The course of the fibre tracts to the thalamus was traced in the subthalamic region using multiple staining procedures and their entrance into the thalamus determined according to our atlas of the human thalamus and basal ganglia [Morel (2007) Stereotactic atlas of the human thalamus and basal ganglia. Informa Healthcare Inc., New York]. Stereotactic three-dimensional coordinates were determined by sectioning thalamic and basal ganglia blocks parallel to stereotactic planes and, in two cases, by correlation with magnetic resonance images (MRI) from the same brains prior to sectioning. The major contributions of this study are to provide: (1) evidence that the bulks of the cerebellothalamic and pallidothalamic tracts are clearly separated up to their thalamic entrance, (2) stereotactic maps of the two tracts in the subthalamic region, (3) the possibility to discriminate between different subthalamic fibre tracts on the basis of immunohistochemical stainings, (4) correlations of histologically identified fibre tracts with high-resolution MRI, and (5) evaluation of the interindividual variability of the fibre systems in the subthalamic region. This study should provide an important basis for accurate stereotactic neurosurgical targeting of the subthalamic region in motor disorders such as PD and ET. |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Switzerland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Czechia | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 174 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 43 | 24% |
| Student > Ph. D. Student | 24 | 13% |
| Other | 19 | 10% |
| Student > Doctoral Student | 15 | 8% |
| Professor > Associate Professor | 14 | 8% |
| Other | 45 | 25% |
| Unknown | 22 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 32% |
| Neuroscience | 36 | 20% |
| Agricultural and Biological Sciences | 17 | 9% |
| Engineering | 12 | 7% |
| Psychology | 7 | 4% |
| Other | 12 | 7% |
| Unknown | 40 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2009.
All research outputs
#8,880,246
of 25,998,826 outputs
Outputs from Brain Structure and Function
#731
of 2,081 outputs
Outputs of similar age
#46,657
of 174,084 outputs
Outputs of similar age from Brain Structure and Function
#2
of 2 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,081 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,084 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.