| Title |
Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea—results from a double-blind cross-over intervention pilot study
|
|---|---|
| Published in |
Archives of Women's Mental Health, April 2018
|
| DOI | 10.1007/s00737-018-0838-x |
| Pubmed ID | |
| Authors |
Farahnaz Keshavarzi, Fariba Mahmoudzadeh, Serge Brand, Dena Sadeghi Bahmani, Fariba Akbari, Habibolah Khazaie, Mohammad Rasoul Ghadami |
| Abstract |
Up to 25% of ovulating women suffer from primary dysmenorrhea, a condition associated with pain and transient-reduced quality of life, along with greater irritability and impaired sleep. In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD). To this end, we conducted a double-blind cross-over clinical trial lasting for three menstrual cycles. A total of 14 women (mean age M = 27.5 years) with primary dysmenorrhea took part in the study. At baseline, that is, during the first menstruation, they completed a visual analogue scale to rate pain; sleep continuity was assessed via actigraphs, and overall sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Next, participants were randomly assigned to one of two conditions, either melatonin during the second, and meloxicam during the third menstruation, or meloxicam during the second, and melatonin during the third menstruation. Neither participants nor investigators were aware of participants' study assignment. During the second and third menstruations, the assessments described above were repeated. At baseline, sleep assessed both objectively and subjectively was impaired, and pain was high. Subjective sleep improved and pain decreased during the second and third menstruations irrespective of whether melatonin or meloxicam was administered first or second. Likewise, objective sleep efficiency increased and objective sleep latency shortened. The efficacy of melatonin was superior to that of meloxicam. The present pattern of results suggests that both melatonin and meloxicam are suitable to treat pain and PD-related sleep complaints among women with primary dysmenorrhea. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 15% |
| Student > Master | 12 | 14% |
| Other | 3 | 4% |
| Lecturer | 3 | 4% |
| Student > Postgraduate | 3 | 4% |
| Other | 10 | 12% |
| Unknown | 41 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 15 | 18% |
| Medicine and Dentistry | 10 | 12% |
| Psychology | 5 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Unspecified | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 42 | 49% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2023.
All research outputs
#14,282,386
of 24,875,365 outputs
Outputs from Archives of Women's Mental Health
#636
of 998 outputs
Outputs of similar age
#165,582
of 334,344 outputs
Outputs of similar age from Archives of Women's Mental Health
#20
of 31 outputs
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