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Mendeley readers
Attention Score in Context
| Title |
Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate
|
|---|---|
| Published in |
The Journal of Immunology, March 2010
|
| DOI | 10.4049/jimmunol.0904013 |
| Pubmed ID | |
| Authors |
Hanne Schoenen, Barbara Bodendorfer, Kelly Hitchens, Silvia Manzanero, Kerstin Werninghaus, Falk Nimmerjahn, Else Marie Agger, Steffen Stenger, Peter Andersen, Jürgen Ruland, Gordon D. Brown, Christine Wells, Roland Lang |
| Abstract |
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in APCs. In this study, we have further investigated the molecular mechanism of innate immune activation by TDM and TDB. The Syk-coupling adapter protein FcRgamma was essential for macrophage activation and Th17 adjuvanticity. The FcRgamma-associated C-type lectin receptor Mincle was expressed in macrophages and upregulated by TDM and TDB. Recombinant Mincle-Fc fusion protein specifically bound to the glycolipids. Genetic ablation of Mincle abolished TDM/TDB-induced macrophage activation and induction of T cell immune responses to a tuberculosis subunit vaccine. Macrophages lacking Mincle or FcRgamma were impaired in the inflammatory response to Mycobacterium bovis bacillus Calmette-Guérin. These results establish that Mincle is a key receptor for the mycobacterial cord factor and controls the Th1/Th17 adjuvanticity of TDM and TDB. |
Mendeley readers
The data shown below were compiled from readership statistics for 269 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 2 | <1% |
| France | 1 | <1% |
| Ireland | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| South Africa | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 259 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 22% |
| Researcher | 49 | 18% |
| Student > Master | 38 | 14% |
| Student > Bachelor | 27 | 10% |
| Professor > Associate Professor | 13 | 5% |
| Other | 41 | 15% |
| Unknown | 43 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 96 | 36% |
| Immunology and Microbiology | 36 | 13% |
| Biochemistry, Genetics and Molecular Biology | 29 | 11% |
| Chemistry | 27 | 10% |
| Medicine and Dentistry | 15 | 6% |
| Other | 23 | 9% |
| Unknown | 43 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2023.
All research outputs
#4,956,108
of 23,760,369 outputs
Outputs from The Journal of Immunology
#4,746
of 30,123 outputs
Outputs of similar age
#20,830
of 96,121 outputs
Outputs of similar age from The Journal of Immunology
#33
of 133 outputs
Altmetric has tracked 23,760,369 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 30,123 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,121 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.