| Title |
Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of β-catenin
|
|---|---|
| Published in |
Clinical & Experimental Metastasis, March 2005
|
| DOI | 10.1007/s10585-005-4578-8 |
| Pubmed ID | |
| Authors |
Xiao-Xin Cheng, Zi-Chuang Wang, Xiao-Yan Chen, Yuan Sun, Qing-You Kong, Jia Liu, Xue Gao, Hong-Wei Guan, Hong Li |
| Abstract |
The potential correlation of E-cadherin reduction and Wnt2 up-regulation in determining the intracellular distribution of beta-catenin in gastric cancers was investigated by the methods of frozen tissue array-based immunohistochemistry, Western blot and RT-PCR analysis. It was revealed that membranous E-cadherin was reduced frequently in the two major subtypes of gastric cancer (intestinal gastric cancer, i-GC and diffuse gastric cancer, d-GC) and closely correlated with the risk of lymphoid node metastasis (P < 0.05). The reduction of membranous E-cadherin was paralleled with cytosolic and nuclear accumulation of beta-catenin and the increased Wnt2 expression. These results indicate that the reduced E-cadherin is a common genetic phenotype of GCs and plays beneficial roles in tumor metastasis. Altered beta-catenin distribution may result from the imbalance of E-cadherin production and Wnt expression, which confers on gastric cancer cells more aggressive behaviors. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 11% |
| Unknown | 8 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 33% |
| Student > Master | 2 | 22% |
| Student > Doctoral Student | 1 | 11% |
| Professor > Associate Professor | 1 | 11% |
| Unknown | 2 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 33% |
| Agricultural and Biological Sciences | 2 | 22% |
| Materials Science | 1 | 11% |
| Neuroscience | 1 | 11% |
| Unknown | 2 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2009.
All research outputs
#7,917,073
of 23,854,458 outputs
Outputs from Clinical & Experimental Metastasis
#210
of 778 outputs
Outputs of similar age
#21,562
of 61,242 outputs
Outputs of similar age from Clinical & Experimental Metastasis
#4
of 8 outputs
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