| Title |
Tauopathies
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2007
|
| DOI | 10.1007/s00018-007-7220-x |
| Pubmed ID | |
| Authors |
F. Hernández, J. Avila |
| Abstract |
Tau is a microtubule-associated protein predominantly expressed in nerve cells that promote microtubule assembly and microtubule stabilization. Tau is a cytosolic protein mainly present in axons and involved in anterograde axonal transport. In several neurodegenerative diseases, as for example Alzheimer's disease, tau metabolism is altered. Thus, alterations in the amount of the tau protein, missense mutations, posttranscriptional modifications like phosphorylation, aberrant tau aggregation or a different expression of some of its isoforms could provoke pathological effects resulting in the appearance of neuronal disorders known as tauopathies. The purpose of this work is to review the possible mechanisms for tau alterations that could lead to the onset of tau pathology. First we will focus on tau turnover, then on tau phosphorylation and, finally, on tau aggregation. |
Mendeley readers
The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 1% |
| Germany | 3 | 1% |
| United States | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 227 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 20% |
| Student > Bachelor | 46 | 20% |
| Student > Master | 41 | 17% |
| Researcher | 23 | 10% |
| Other | 12 | 5% |
| Other | 27 | 11% |
| Unknown | 40 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 24% |
| Biochemistry, Genetics and Molecular Biology | 30 | 13% |
| Neuroscience | 27 | 11% |
| Medicine and Dentistry | 26 | 11% |
| Chemistry | 21 | 9% |
| Other | 30 | 13% |
| Unknown | 44 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2021.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#13,576
of 69,650 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#10
of 28 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,650 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.