| Title |
Statins and dementia
|
|---|---|
| Published in |
Current Atherosclerosis Reports, April 2007
|
| DOI | 10.1007/s11883-007-0012-9 |
| Pubmed ID | |
| Authors |
Lewis H. Kuller |
| Abstract |
The incidence and prevalence of dementia are increasing. Dementia is a major cause of disability. Alzheimer's disease (AD) is the most common type of dementia. There are no good prevention or treatment options. Experimental animal and laboratory studies have suggested that cholesterol metabolism in the brain is important in the causal pathway for dementia, possibly by modifying amyloid metabolism. A few studies have showed a possible relationship between mid-life blood cholesterol levels and risk of dementia, including AD. Case-control studies report that patients with AD were less likely to use lipid-lowering drugs, especially statins. Longitudinal epidemiology studies have not demonstrated a decreased risk of AD among statin users versus nonusers. Two clinical trials of statin therapy to reduce cardiovascular disease have not shown any reduction in risk of cognitive decline or dementia. The results of two secondary prevention trials will be reported shortly. In spite of negative studies, the possibility remains that statin therapy may reduce risk of dementia and AD. Primary prevention trials are difficult and expensive and will likely not be done in the United States. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Master | 5 | 16% |
| Student > Ph. D. Student | 5 | 16% |
| Student > Bachelor | 4 | 13% |
| Other | 3 | 10% |
| Other | 5 | 16% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 45% |
| Agricultural and Biological Sciences | 4 | 13% |
| Psychology | 3 | 10% |
| Social Sciences | 1 | 3% |
| Linguistics | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 6 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2019.
All research outputs
#8,517,130
of 25,392,205 outputs
Outputs from Current Atherosclerosis Reports
#405
of 860 outputs
Outputs of similar age
#30,345
of 86,144 outputs
Outputs of similar age from Current Atherosclerosis Reports
#4
of 8 outputs
Altmetric has tracked 25,392,205 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 860 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.