| Title |
Frontal cortical control of posterior sensory and association cortices through the claustrum
|
|---|---|
| Published in |
Brain Structure and Function, April 2018
|
| DOI | 10.1007/s00429-018-1661-x |
| Pubmed ID | |
| Authors |
Michael G. White, Brian N. Mathur |
| Abstract |
The claustrum is a telencephalic gray matter nucleus that is richly interconnected with the neocortex. This structure subserves top-down executive functions that require frontal cortical control of posterior cortical regions. However, functional anatomical support for the claustrum allowing for long-range intercortical communication is lacking. To test this, we performed a channelrhodopsin-assisted long-circuit mapping strategy in mouse brain slices. We find that anterior cingulate cortex input to the claustrum is transiently amplified by claustrum neurons that, in turn, project to parietal association cortex or to primary and secondary visual cortices. Additionally, we observe that claustrum drive of cortical neurons in parietal association cortex is layer-specific, eliciting action potential generation briefly in layers II/III, IV, and VI but not V. These data are the first to provide a functional anatomical substrate through claustrum that may underlie top-down functions, such as executive attention or working memory, providing critical insight to this most interconnected and enigmatic nucleus. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 82% |
| Canada | 2 | 18% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 45% |
| Scientists | 5 | 45% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 82 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 27% |
| Student > Ph. D. Student | 16 | 20% |
| Student > Bachelor | 10 | 12% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 5 | 6% |
| Other | 7 | 9% |
| Unknown | 14 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 26% |
| Agricultural and Biological Sciences | 13 | 16% |
| Medicine and Dentistry | 9 | 11% |
| Linguistics | 7 | 9% |
| Psychology | 5 | 6% |
| Other | 10 | 12% |
| Unknown | 17 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2018.
All research outputs
#4,540,281
of 24,217,893 outputs
Outputs from Brain Structure and Function
#335
of 1,725 outputs
Outputs of similar age
#85,095
of 332,993 outputs
Outputs of similar age from Brain Structure and Function
#13
of 41 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.