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Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

Overview of attention for article published in eLife, April 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

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1 news outlet
blogs
1 blog
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13 X users

Citations

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25 Dimensions

Readers on

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58 Mendeley
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Title
Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish
Published in
eLife, April 2018
DOI 10.7554/elife.32965
Pubmed ID
Authors

Sharan Janjuha, Sumeet Pal Singh, Anastasia Tsakmaki, S Neda Mousavy Gharavy, Priyanka Murawala, Judith Konantz, Sarah Birke, David J Hodson, Guy A Rutter, Gavin A Bewick, Nikolay Ninov

Abstract

The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from younger and older zebrafish, here we show that the aging islets exhibit signs of chronic inflammation. These include recruitment of tnfα-expressing macrophages and the activation of NF-kB signaling in beta-cells. Using a transgenic reporter, we show that NF-kB activity is undetectable in juvenile beta-cells, whereas cells from older fish exhibit heterogeneous NF-kB activity. We link this heterogeneity to differences in gene expression and proliferation. Beta-cells with high NF-kB signaling proliferate significantly less compared to their neighbors with low activity. The NF-kB signalinghi cells also exhibit premature upregulation of socs2, an age-related gene that inhibits beta-cell proliferation. Together, our results show that NF-kB activity marks the asynchronous decline in beta-cell proliferation with advancing age.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 34%
Student > Master 8 14%
Student > Bachelor 7 12%
Student > Doctoral Student 5 9%
Researcher 5 9%
Other 3 5%
Unknown 10 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 40%
Agricultural and Biological Sciences 10 17%
Immunology and Microbiology 3 5%
Social Sciences 2 3%
Neuroscience 2 3%
Other 5 9%
Unknown 13 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2018.
All research outputs
#1,728,556
of 23,322,258 outputs
Outputs from eLife
#5,258
of 14,179 outputs
Outputs of similar age
#39,928
of 330,330 outputs
Outputs of similar age from eLife
#138
of 338 outputs
Altmetric has tracked 23,322,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,179 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.9. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,330 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 338 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.