| Title |
The Integrated Alzheimer’s Disease Rating Scale (iADRS) Findings from the EXPEDITION3 Trial
|
|---|---|
| Published in |
The Journal of Prevention of Alzheimer's Disease, February 2018
|
| DOI | 10.14283/jpad.2018.10 |
| Pubmed ID | |
| Authors |
Alette M. Wessels, S. W. Andersen, S. A. Dowsett, E. R. Siemers |
| Abstract |
The Integrated Alzheimer's Disease (AD) Rating Scale (iADRS) is a composite tool that combines scores from the AD Assessment Scale-Cognitive subscale (ADAS-Cog) and the AD Cooperative Study - instrumental Activities of Daily Living (ADCS-iADL). It demonstrates acceptable psychometric properties, and is effective in capturing both disease progression and separation of placebo and active drug effect. We assessed the performance of iADRS in the solanezumab EXPEDITION3 study, an 80-week, placebo-controlled study of individuals with mild AD dementia. A statistically significant difference between placebo and active drug was observed for iADRS score change from baseline at Week 28 (p=0.028) through Week 80 (p=0.015). Across the Phase 3 solanezumab trials, iADRS was the only tool that consistently differentiated between solanezumab and placebo groups. These findings suggest that the iADRS is a useful integrated measurement tool for treatment trials of individuals with mild AD dementia. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 18% |
| Researcher | 7 | 18% |
| Student > Master | 4 | 10% |
| Lecturer > Senior Lecturer | 1 | 3% |
| Professor | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 17 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 13% |
| Medicine and Dentistry | 4 | 10% |
| Agricultural and Biological Sciences | 3 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Psychology | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 18 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 73. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#585,618
of 25,382,440 outputs
Outputs from The Journal of Prevention of Alzheimer's Disease
#27
of 595 outputs
Outputs of similar age
#13,515
of 344,345 outputs
Outputs of similar age from The Journal of Prevention of Alzheimer's Disease
#1
of 10 outputs
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