Robust multi-label transfer feature learning for early diagnosis of Alzheimer’s disease

Bo Cheng, Mingxia Liu, Daoqiang Zhang, Dinggang Shen, Alzheimer’s Disease Neuroimaging Initiative

Transfer learning has been successfully used in the early diagnosis of Alzheimer's disease (AD). In these methods, data from one single or multiple related source domain(s) are employed to aid the learning task in the target domain. However, most of the existing methods utilize data from all source domains, ignoring the fact that unrelated source domains may degrade the learning performance. Also, previous studies assume that class labels for all subjects are reliable, without considering the ambiguity of class labels caused by slight differences between early AD patients and normal control subjects. To address these issues, we propose to transform the original binary class label of a particular subject into a multi-bit label coding vector with the aid of multiple source domains. We further develop a robust multi-label transfer feature learning (rMLTFL) model to simultaneously capture a common set of features from different domains (including the target domain and all source domains) and to identify the unrelated source domains. We evaluate our method on 406 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database with baseline magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) data. The experimental results show that the proposed rMLTFL method can effectively improve the performance of AD diagnosis, compared with several state-of-the-art methods.