| Title |
The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, June 2007
|
| DOI | 10.1007/s00018-007-7162-3 |
| Pubmed ID | |
| Authors |
M. Štros, D. Launholt, K. D. Grasser |
| Abstract |
The HMG-box domain of approximately 75 amino acid residues was originally identified as the domain that mediates the DNA-binding of chromatin-associated high-mobility group (HMG) proteins of the HMGB type. In the last few years, HMG-box domains have been found in various DNA-binding proteins including transcription factors and subunits of chromatin-remodeling complexes. HMG-box domains mediate either non-sequence-specific (e.g., HMGB-type proteins) or sequence-specific (e.g., transcription factors) DNA binding. Both types of HMG-box domains bind non-B-type DNA structures (bent, kinked and unwound) with high affinity. In addition, HMG-box domains are involved in a variety of protein-protein interactions. Here, we have examined the human and plant genomes for genes encoding HMG-box domains. Compared to plants, human cells contain a larger variety of HMG-box proteins. Whereas in humans transcription factors are the most divergent group of HMG-box proteins, in plants the chromosomal HMGB-type proteins are most variable. |
Mendeley readers
The data shown below were compiled from readership statistics for 255 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Spain | 2 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Norway | 1 | <1% |
| Australia | 1 | <1% |
| Taiwan | 1 | <1% |
| Unknown | 246 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 27% |
| Researcher | 38 | 15% |
| Student > Bachelor | 33 | 13% |
| Student > Master | 27 | 11% |
| Student > Doctoral Student | 19 | 7% |
| Other | 36 | 14% |
| Unknown | 33 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 110 | 43% |
| Biochemistry, Genetics and Molecular Biology | 80 | 31% |
| Medicine and Dentistry | 10 | 4% |
| Neuroscience | 3 | 1% |
| Chemistry | 3 | 1% |
| Other | 11 | 4% |
| Unknown | 38 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2019.
All research outputs
#8,882,501
of 26,017,215 outputs
Outputs from Cellular and Molecular Life Sciences
#2,292
of 6,041 outputs
Outputs of similar age
#29,902
of 82,045 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#16
of 28 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,041 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,045 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.