| Title |
Age, sex, and puberty related development of the corpus callosum: a multi-technique diffusion MRI study
|
|---|---|
| Published in |
Brain Structure and Function, April 2018
|
| DOI | 10.1007/s00429-018-1658-5 |
| Pubmed ID | |
| Authors |
Sila Genc, Charles B. Malpas, Gareth Ball, Timothy J. Silk, Marc L. Seal |
| Abstract |
The corpus callosum is integral to the central nervous system, and continually develops with age by virtue of increasing axon diameter and ongoing myelination. Magnetic resonance imaging (MRI) techniques offer a means to disentangle these two aspects of white matter development. We investigate the profile of microstructural metrics across the corpus callosum, and assess the impact of age, sex and pubertal development on these processes. This study made use of two independent paediatric populations. Multi-shell diffusion MRI data were analysed to produce a suite of diffusion tensor imaging, neurite orientation dispersion and density imaging, and apparent fibre density (AFD) metrics. A multivariate profile analysis was performed for each diffusion metric across ten subdivisions of the corpus callosum. All diffusion metrics significantly varied across the length of the corpus callosum. AFD exhibited a strong relationship with age across the corpus callosum (partial η2 = 0.65), particularly in the posterior body of the corpus callosum (partial η2 = 0.72). In addition, females had significantly higher AFD compared with males, most markedly in the anterior splenium (partial η2 = 0.14) and posterior genu (partial η2 = 0.13). Age-matched pubertal group differences were localised to the splenium. We present evidence of a strong relationship between apparent fibre density and age, sex, and puberty during development. These results are consistent with ex vivo studies of fibre morphology, providing insights into the dynamics of axonal development in childhood and adolescence using diffusion MRI. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 17% |
| United States | 2 | 17% |
| Canada | 1 | 8% |
| Norway | 1 | 8% |
| Australia | 1 | 8% |
| Unknown | 5 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 75% |
| Scientists | 3 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 17% |
| Researcher | 12 | 14% |
| Student > Master | 8 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Student > Postgraduate | 6 | 7% |
| Other | 15 | 18% |
| Unknown | 21 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 20% |
| Medicine and Dentistry | 12 | 14% |
| Psychology | 9 | 11% |
| Agricultural and Biological Sciences | 3 | 4% |
| Physics and Astronomy | 2 | 2% |
| Other | 8 | 10% |
| Unknown | 32 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2019.
All research outputs
#4,961,908
of 24,217,893 outputs
Outputs from Brain Structure and Function
#376
of 1,725 outputs
Outputs of similar age
#91,805
of 333,184 outputs
Outputs of similar age from Brain Structure and Function
#16
of 43 outputs
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