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Purine and Pyrimidine Metabolism in Man IX

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Table of Contents

  1. Altmetric Badge
    Book Overview
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    Chapter 1 Gout New Questions for an Ancient Disease
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    Chapter 2 Efficacy of Allopurinol in Ameliorating the Progressive Renal Disease in Familial Juvenile Hyperuricaemic Nephropathy (FJHN)
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    Chapter 3 Optimal Range of Serum Urate Concentrations to Minimize Risk of Gouty Attacks During Anti-Hyperuricemic Treatment
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    Chapter 4 How Should we Treat Tophaceous Gout in Patients with Allopurinol Hypersensitivity?
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    Chapter 5 The Spectrum of HGPRT Deficiency
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    Chapter 6 Plasma Uridine as well as Uric Acid is Elevated Following Fructose Loading
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    Chapter 7 Inverse relationship between serum triglyceride levels and fractional urate excretion.
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    Chapter 8 Microanalysis of Pathological Crystals and Urinary Calculi
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    Chapter 9 Zonal Distribution of Allopurinol-Oxidizing Enzymes in Rat Liver
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    Chapter 10 Severe Debilitating Polyarticular Gout and Terminal Renal Failure in an Allopurinol ‘Non-Responder’
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    Chapter 11 Decreased Serum Concentrations of 1,25(OH)2-Vitamin D3 in Patients with Gout
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    Chapter 12 Lipoproteins in Patients with Isolated Hyperuricemia
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    Chapter 13 Atherogenic Risk Factors in Patients with Gout
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    Chapter 14 Cardiovascular Actions of Adenosine
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    Chapter 15 Mast Cell Adenosine Receptor Characteristics and Signaling
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    Chapter 16 Purine and Pyrimidine Nucleoside Content of the Neuronal Extracellular Space in Rat
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    Chapter 17 Effect of FMLP Stimulation on [ 3 H]-NECA Binding to Adenosine Receptors in Neutrophils Membranes
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    Chapter 18 Effects of nucleoside transport inhibitors and adenine/ribose on ATP concentration and adenosine production in cardiac myocytes.
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    Chapter 19 Purification of a Protein Involved in ADP Formation
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    Chapter 20 ADP Formation In Rat Liver
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    Chapter 21 A 1 Adenosine Receptors in Human Neutrophils
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    Chapter 22 Purification and Some Molecular Properties of Pigeon Heart AMP-Selective 5′-Nucleotidase
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    Chapter 23 Succinylpurines do not Modify Glutamate or Adenosine Effects in the CNS
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    Chapter 24 Clinical and Biochemical Aspects of Dihydropyrimidinase Deficiency
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    Chapter 25 The Genetic Basis of Myoadenylate Deaminase Deficiency is Heterogeneous
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    Chapter 26 The Origin of APRT*J the Most Common Disease-Related Mutation of APRT Gene Among Japanese Goes Back to a Prehistoric Era
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    Chapter 27 HGPRT and Aprt Activities in Hemolysates During the First Year of Life
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    Chapter 28 Delayed Hypersensitivity to 5-Fluorouracil Associated with Reduced Dihydropyrimidine Dehydrogenase (DPD) Activity
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    Chapter 29 HPRT-Mutations in Italian Lesch-Nyhan Patients
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    Chapter 30 Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF).
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    Chapter 31 Erythrocyte UMP Synthetase Activity
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    Chapter 32 Nonrandom Selection of Hair Follicles in HPRT Heterozygosity
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    Chapter 33 Optimised Micellar Electrokinetic Capillary Chromatography of UV-Absorbing Compounds in Urine
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    Chapter 34 Effect of D-Ribose Administration to a Patient with Inherited Deficit of Adenylosuccinase
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    Chapter 35 Enzyme Activities Leading to NAD Synthesis in the Erythrocytes of Hprt Deficient Subjects
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    Chapter 36 Succinylpurines Induce Neuronal Damage in the Rat Brain
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    Chapter 37 Urinary Screening for Pyrimidine Metabolism Disorders
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    Chapter 38 Carrier State in Hgprt Deficiency a Study in 14 Spanish Families
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    Chapter 39 Genetic Diagnosis of Hypoxanthine-Guanine Phosphoribosyltransferase (Hgprt) Carrier Status by Restriction Analysis and Directed Mutagenesis
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    Chapter 40 Muscle Purine Nucleotide Cycle Enzymes in Exercise Intolerance
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    Chapter 41 Prenatal Diagnosis of HPRT Mutant Genes in Lesch-Nyhan Syndrome
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    Chapter 42 Regulation of Human PRS Isoform Expression
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    Chapter 43 Structure and functional relationships in human pur H.
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    Chapter 44 Localization of Carbamoyl-Phosphate Synthetase II (Cps Ii) and Aspartate Carbamoyltransferase (Act) Genes in trypanosoma Cruzi Chromosomal DNA
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    Chapter 45 Expression and Characterization of Recombinant Bovine Cytosolic 5′-Nucleotidase IMP-GMP Specific
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    Chapter 46 Molecular Characterization of a Carbamoyl-Phosphate Synthetase II (Cps II) Gene from leishmania Mexicana
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    Chapter 47 Substrate Channelling by Human IMP Synthase
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    Chapter 48 Inhibition of Adenylosuccinate Lyase By 2′, 3′-Acyclic Substrate Analogs
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    Chapter 49 Regulation of Deoxycytidine Kinase by Deoxycytidine and Deoxycytidine 5′ Triphosphate in Whole Leukemia and Tumor Cells
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    Chapter 50 Kinetic Properties of CTP Synthetase from Hl-60 Cells
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    Chapter 51 cellulomonas sp . Purine Nucleoside Phosphorylase (PNP)
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    Chapter 52 Subdomain Structure of Carbamyl Phosphate Synthetase
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    Chapter 53 The effects of nucleotide pool on purine production in the postischemic heart.
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    Chapter 54 Muscle Energy Metabolism in Human Adenylosuccinase Deficiency
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    Chapter 55 Cardioprotection by Ischemic Preconditioning
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    Chapter 56 High-energy phosphate changes in the normal and hypertrophied heart during cardioplegic arrest and ischemia.
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    Chapter 57 Role of Glutamate-67 in the Catalytic Mechanism of Human Cytidine Deaminase
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    Chapter 58 Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity.
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    Chapter 59 Site Directed Mutagenesis of the saccharomyces Cerevisiae Apt1 Gene
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    Chapter 60 Studies on Cysteine Residues Involved in the Active Site of Human Cytidine Deaminase
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    Chapter 61 Relationship of the Two APRT Gene Products from saccharomyces Cerevisiae
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    Chapter 62 Structural and Functional Analysis of the Human TPMT Gene Promoter
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    Chapter 63 A First Evidence of an Asymptomatic Germline Missense Base Substitution in the Hypoxanthine Phosphoribosyltransferase (HPRT) Gene in Humans
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    Chapter 64 Genetic Basis of Adenylosuccinase Deficiency in an Italian Patient
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    Chapter 65 Mutations in Xanthine Dehydrogenase Gene in Subjects with Hereditary Xanthinuria
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    Chapter 66 Role of Cysteine and Lysine Residues in Human Hypoxanthine-Guanine Phosphoribosyltransferase
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    Chapter 67 Molecular Analysis of Mouse ampd3 Gene Encoding Heart-Type Isoform of Amp Deaminase
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    Chapter 68 Dihydropyrimidine Dehydrogenase Deficiency
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    Chapter 69 Gene Mutations Responsible for Human Erythrocyte AMP Deaminase Deficiency in Poles
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    Chapter 70 Response of Purine Metabolism to Hypoxia and Ischemia
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    Chapter 71 Endothelial Purine Metabolism and Reperfusion Injury
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    Chapter 72 Adenosine-Induced Preconditioning of Rat Neuronal Cultures Against Ischemia-Reperfusion Injury
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    Chapter 73 Myocardial Ischemic Injury During Cardio-Pulmonary by-Pass
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    Chapter 74 Nucleotide metabolism in the heart subjected to heat stress.
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    Chapter 75 Differences in nucleotide metabolism and mechanical recovery after cardioplegic arrest of the heart at different age.
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    Chapter 76 Different mechanism of myocardial nucleotide breakdown during normothermic and hypothermic ischemia
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    Chapter 77 Effects of adenine/ribose supply on adenosine production and ATP concentration in adenosine kinase inhibited cardiac cells.
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    Chapter 78 A Nucleotide and Nucleosides Mixture Solution Improves Recovery of Energy Metabolism after Hepatic Ischemia in Rats
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    Chapter 79 Can Adenosine Deaminase Inhibitors be Cytoprotective Agents?
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    Chapter 80 Role of Purine Metabolism in Regulation of Signal Transduction in Human Carcinoma Cells
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    Chapter 81 Role Of Adenosine Deaminase and dATP Levels in Thymocyte Apoptosis
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    Chapter 82 Structure and Function of P2Y 2 Nucleotide Receptors in Cystic Fibrosis (CF) Epithelium
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    Chapter 83 Deoxycytidine Kinase can be also Potentiated by the G-Protein Activator NaF in Cells
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    Chapter 84 Low GTP Induces PKC-β-Dependent Myeloid Cell Differentiation
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    Chapter 85 Exogenous S-Adenosyl-Methionine Methylates Phospholipids Located on the Outer Cell Surface of Isolated Rat Hepatocytes
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    Chapter 86 Imp-Dehydrogenase (IMPDH), Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT), and Phosphodiesterases (PDEs) Expression During Mycophenolic Acid (MPA)-Induced Differentiation in Human Neuroblastoma Cell Lines
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    Chapter 87 Differentiating and Biochemical Effects of a Reduction of Intracellular GTP Levels Induced by Mycophenolic Acid (MPA) in Human Neuroblastoma (NB) Cell Lines
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    Chapter 88 New Models for the Study of Adenosine Deaminase Deficiency
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    Chapter 89 Insights into Adenosine Deaminase Deficiency Provided by Murine Fetal Thymic Organ Culture with 2′-Deoxycoformycin
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    Chapter 90 Thymidine Kinase Expression
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    Chapter 91 Neuroblastoma Cell Apoptosis Induced by Mycophenolic Acid
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    Chapter 92 The single deoxynucleoside kinase in Drosophila melanogaster, Dm-dNK, is multifunctional and differs from the mammalian deoxynucleoside kinases.
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    Chapter 93 Effect of Deoxynucleosides on the Repair of UV Induced DNA Breaks
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    Chapter 94 A New Model Organism for Studying the Catabolism of Pyrimidines and Purines
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    Chapter 95 Cad Overexpression in Mammalian Cells
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    Chapter 96 Azathioprine Treatment and Thiopurine Metabolism in Rheumatic Diseases
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    Chapter 97 Identification of Multiple forms of the Cytosolic 5′-Nucleotidase/Phosphotransferase in Rat Tissues
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    Chapter 98 Regulation of Deoxynucleotide Pools by Substrate Cycles
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    Chapter 99 Dihydroorotate Dehydrogenase
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    Chapter 100 Purine Nucleoside Phosphorylase Deficient Mice Exhibit Both an Age Dependent Attrition of Thymocytes and Impaired Thymocyte Differentiation
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    Chapter 101 Activation of Deoxycytidine Kinase During Inhibition of DNA Synthesis in Human Lymphocytes
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    Chapter 102 Similar Changes Were Induced by Cladribine and by Gemcitabine, in the Deoxypyrimidine Salvage, During Short Term Treatments
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    Chapter 103 Effect of Cladribine, Fludarabine, and 5-AZA-Deoxycytidine on S-Adenosylmethionine (SAM) and Nucleotides Pools in Stimulated Human Lymphocytes
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    Chapter 104 Inhibition of Inosine Monophosphate Dehydrogenase Activity by the Plasma of Heart Transplant Recipients Receiving Mycophenolate Mofetil
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    Chapter 105 Changes of Polymorphonuclear Leukocyte (PMN) Functions Under Dietary Nucleic Acid Deficiency and Effects of Administration of Nucleotide and Nucleosides Mixture Solution in Mice
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    Chapter 106 Differentiation and Reduction of Intracellular GTP Levels in Hl-60 and U937 Cells Upon Treatment with IMP Dehydrogenase Inhibitors
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    Chapter 107 Isoenzymes of 5′-Nucleotidase in Human Lymphocytes
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    Chapter 108 Biochemical basis for the impaired immune response in chronic renal failure?
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    Chapter 109 Mycophenolic Acid Influences the Expression of ICAM-1 on Human Endothelial Cells
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    Chapter 110 Reaction of 2′, 3′-Dideoxynucleotides Triphosphates with Recombinant Human Nucleoside Diphosphate Kinase
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    Chapter 111 Antitumor Activity of Yunnanmycin
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    Chapter 112 Mechanisms of Synergism Between Gemcitabine and Cisplatin
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    Chapter 113 Cross-Resistance of the Gemcitabine Resistant Human Ovarian Cancer Cell Line AG6000 to Standard and Investigational Drugs
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    Chapter 114 Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines.
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    Chapter 115 Does 2-Chlorodeoxyadenosine Contribute to Alteration of DNA Methyltransferase Activity?
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    Chapter 116 Iron Binding Capacity of Didox (3,4 Dihydroxybenzohydroxamic Acid) and Amidox (3,4 Dihydroxybenzamidoxime) two Inhibitors of the Enzyme Ribonucleotide Reductase
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    Chapter 117 In Vitro and in Vivo Inhibitory Activity of the Differentiation-Inducing Agent 9-(2-Phosphonylmethoxyethyl)Adenine (Pmea) Against Rat Choriocarcinoma
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    Chapter 118 Increased Cell Killing and Mutagenecity by DNA Alkylating Agents in Cells with Decreased TTP Pools
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    Chapter 119 N 4 -Hydroxy-5-Halogeno-2′-Deoxycytidine S and Their 5′-Mono-Phosphates as Inhibitors of Thymidylate Synthase and in Vitro Antileukemic Agents
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    Chapter 120 Substrate/Inhibitor Specificities of Human Deoxycytidine Kinase (DCK) and Thymidine Kinases (TK1 and TK2)
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    Chapter 121 Investigation of Isoenzymes of Adenylosuccinase in Human Blood Cells
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    Chapter 122 Dihydropyrimidine Dehydrogenase in Livers from Mouse and Rat, and in Human Liver, Colon Tumors, and Mucosa in Relation to Anabolism of 5-Fluorouracil
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    Chapter 123 Induction of in Vivo Resistance Against Gemcitabine (dFdC,2′,2′-Difluoro-Deoxycytidine)
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    Chapter 124 Activation of Deoxycytidine Kinase by Various Nucleoside Analogues
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    Chapter 125 Clinical Pharmacology of Intermediate and Low-Dose Cytosine Arabinoside (ara-C) Therapy in Patients with Hematologic Malignancies
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    Chapter 126 The Role of Thymidine Kinase Activity in Murine Colon Tumours Treated with 5-Fluorouracil
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    Chapter 127 Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC).
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    Chapter 128 Differential Effects of Gemcitabine on Nucleotide Pools of 19 Solid Tumor Cell Lines
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    Chapter 129 Increased Activity of Cytidine triphosphate Synthetase in Pediatric Acute Lymphoblastic Leukemia
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    Chapter 130 Expression of Human Cytosolic Thymidine Kinase in Escherichia Coli
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    Chapter 131 Structure-Activity Relationship in Ftorafur (Tegafur) and Related 5-Fu Prodrugs
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    Chapter 132 Measurement of Mutation Frequency at the HPRT Locus in Peripheral Lymphocytes
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    Chapter 133 Thiopurine Treatment in Childhood Leukemia
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    Chapter 134 Relationship Between Cladribine (CDA) Plasma, Intracellular Cda-5′-Triphosphate (CDATP) Concentration, Deoxycytidine Kinase (DCK), and Chemotherapeutic Activity in Chronic Lymphocytic Leukemia (CLL)
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    Chapter 135 Determinants of the Therapeutic Efficacy of Thymidylate Synthase Inhibitors
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    Chapter 136 Pyrimidine Antagonists and Antifolates as Antimalarial Drugs
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    Chapter 137 Adenine Nucleoside Phosphorylases in Trematode Fasciola Hepatica , the Mammalian Parasite
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    Chapter 138 Inhibition by 3′-Azido-3′-Deoxythymidine (AZT) of trypanosoma Cruzi Growth in Mammalian Cells and a Possible Mechanism of Action
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    Chapter 139 Metabolism of Eicar (5-Ethynyl-1-β-D- Ribofuranosylimidazole-4-Carboxamide),A Potent Inhibitor of Inosinate Dehydrogenase
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    Chapter 140 A HPLC Method for the Monitoring of Human Red Cell 6-Thioguanine and Methyl 6-Mercaptopurine in a Single Run
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    Chapter 141 Expression and Properties of Recombinant P. Falciparum Hypoxanthine-Guanine Phosphoribosyltransferase
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    Chapter 142 Determination of Thiopurine Methyltransferase Activity in Erythrocytes Using 6-Thioguanine as the Substrate
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    Chapter 143 Antiviral Acyclic Nucleoside Phosphonate Analogues as Inhibitors of Purine Nucleoside Phosphorylase
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    Chapter 144 Metabolism and Anti-HIV Activity of Phosphoramidate Derivatives of D4T-MP with Variations in the Amino Acid Moiety
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    Chapter 145 Determination of Purine Enzyme Activities in Human Erythrocytes by Capillary Electrophoresis
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    Chapter 146 Capillary Electrophoretic Analysis of Hypoxanthine and Xanthine for the Diagnosis of Xanthinuria
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    Chapter 147 Ecto-Nucleotidases in Isolated Intact Rat Vagi, Nodose Ganglia, and Superior Cervical Ganglia
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    Chapter 148 Hypoxanthine and Xanthine as Markers in Early Diagnosis of Foetal Diseases
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    Chapter 149 Effects of dipyridamole and adenine/ribose on ATP concentration and adenosine production in cardiac myocytes.
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    Chapter 150 Evaluation of adenine concentration in plasma of patients with renal failure using improved ultrafiltration technique.
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    Chapter 151 A Syndrome of Seizures and Pervasive Developmental Disorder Associated with Excessive Cellular Nucleotidase Activity
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    Chapter 152 de Novo Purine Synthesis is Increased in the Fibroblasts of Purine Autism Patients
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    Chapter 153 Determination and Separation of Allantoin, Uric Acid, Hypoxanthine, and Xanthine by Capillary Zone Electrophoresis
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    Chapter 154 Pharmacokinetics of Mycophenolate Mofetil in Heart Transplant Recipients
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    Chapter 155 Immunohistochemical Analysis of P185 and ASL Activity in Pre-Neoplastic Lesions and Intestinal Mucosa of Human Subjects
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    Chapter 156 No Circadian Variation of Dihydropyrimidine Dehydrogenase, Uridine Phosphorylase, β-Alanine, and 5-Fluorouracil During Continuous Infusion of 5-Fluorouracil
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    Chapter 157 Subcellular Localization of Dihydropyrimidine Dehydrogenase
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    Chapter 158 The Activity of Dihydropyrimidine Dehydrogenase in Human Blood Cells
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    Chapter 159 Endothelial Purine Content
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    Chapter 160 Influence of Glycopeptide Antibiotics on Purine Metabolism of Endothelial Cells
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    Chapter 161 Effect of Tofu (bean curd) ingestion and on uric acid metabolism in healthy and gouty subjects.
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    Chapter 162 Purines and Pyrimidines Determination in Urine Using High-Performance Liquid Chromatography
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    Chapter 163 Design, Synthesis, and Structure-Activity Relationships of the First Highly Potent, Selective, and Bio Available Adenosine 5′-Monophosphate Deaminase Inhibitors
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    Chapter 164 Design and Synthesis of the First Potent, Selective, and Cell Penetrating Adenosine 5′-Monophosphate Deaminase Inhibitors
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    Chapter 165 Erratum to: Effects of Nucleoside Transfort Inhibitors and Adenine/Riboseon ATP Concentration and Adenosine Production in Cardiac Myocytes
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    Chapter 166 Erratum to: Energy Metabolism in the Failing Human Heart with Dilated or Hypertrophic Cardiomyopathy.
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Title
Purine and Pyrimidine Metabolism in Man IX
Published by
Springer US, December 2012
DOI 10.1007/978-1-4615-5381-6
ISBNs
978-1-4613-7456-5, 978-1-4615-5381-6
Editors

Griesmacher, Andrea, Müller, Mathias M., Chiba, Peter

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Geographical breakdown

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Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 17%
Professor > Associate Professor 1 8%
Student > Master 1 8%
Unknown 8 67%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 17%
Biochemistry, Genetics and Molecular Biology 1 8%
Medicine and Dentistry 1 8%
Unknown 8 67%