Title |
Replication of reported linkages for dyslexia and spelling and suggestive evidence for novel regions on chromosomes 4 and 17
|
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Published in |
European Journal of Human Genetics, November 2006
|
DOI | 10.1038/sj.ejhg.5201739 |
Pubmed ID | |
Authors |
Timothy C Bates, Michelle Luciano, Anne Castles, Max Coltheart, Margaret J Wright, Nicholas G Martin |
Abstract |
We report the first genome-wide linkage analysis for reading and spelling in a sample of 403 families of twins, aged between 12 and 25 years taken from the normal population and unselected for reading ability. These traits showed heritabilities of 0.52-0.73, and support for linkage exceeded replication levels (lod > 1.44) of seven of the 11 linkages reported in dyslexic samples, namely: 2q22.3, 3p12-q13, 6q11.2, 7q32, 15q21.1, 18p21, and Xq27.3. For five of these (2q22.3, 6q11.2, 7q32, 18p21, and Xq27), this study provides the first independent replication. 1p34-36 and 2p15-16 received some support, with lods of 1.2 and 0.83, respectively, whereas two regions received little support (6p23-21.3 and 11p15.5). This study also identified two novel linkages at 4p15.33-16.1 and 17p13.3, which received suggestive support (max. lod 2.08 and 1.99, respectively). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 21% |
Researcher | 6 | 14% |
Professor | 6 | 14% |
Student > Doctoral Student | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 8 | 19% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 28% |
Psychology | 10 | 23% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Medicine and Dentistry | 3 | 7% |
Linguistics | 2 | 5% |
Other | 5 | 12% |
Unknown | 8 | 19% |