| Title |
Clinical and genetic aspects of defects in the mitochondrial iron–sulfur cluster synthesis pathway
|
|---|---|
| Published in |
JBIC Journal of Biological Inorganic Chemistry, April 2018
|
| DOI | 10.1007/s00775-018-1550-z |
| Pubmed ID | |
| Authors |
A. V. Vanlander, R. Van Coster |
| Abstract |
Iron-sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic cells. The biosynthesis pathways of the iron-sulfur clusters are located in the mitochondria and in the cytosol. The mitochondrial iron-sulfur cluster biosynthesis pathway (ISC) can be divided into at least twenty enzymatic steps. Since the description of frataxin deficiency as the cause of Friedreich's ataxia, multiple other deficiencies in ISC biosynthesis pathway have been reported. In this paper, an overview is given of the clinical, biochemical and genetic aspects reported in humans affected by a defect in iron-sulfur cluster biosynthesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 24% |
| Researcher | 8 | 19% |
| Student > Bachelor | 4 | 10% |
| Student > Master | 3 | 7% |
| Student > Doctoral Student | 1 | 2% |
| Other | 5 | 12% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 21% |
| Agricultural and Biological Sciences | 5 | 12% |
| Medicine and Dentistry | 4 | 10% |
| Chemistry | 3 | 7% |
| Business, Management and Accounting | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 13 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2018.
All research outputs
#21,180,380
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Outputs from JBIC Journal of Biological Inorganic Chemistry
#590
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#293,219
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Outputs of similar age from JBIC Journal of Biological Inorganic Chemistry
#9
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